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Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications

We have evaluated the effect of buspirone (1.5 mg/kg/day, p.o.) type 1 diabetes induced cardiovascular complications induced by streptozotocin (STZ, 45 mg/kg, i.v.) in Wistar rats. Various biochemical, cardiovascular, and hemodynamic parameters were measured at the end of 8 weeks of treatment. STZ p...

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Autores principales: Raghunathan, Suchi, Tank, Pratik, Bhadada, Shraddha, Patel, Bhoomika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915896/
https://www.ncbi.nlm.nih.gov/pubmed/24563867
http://dx.doi.org/10.1155/2014/948427
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author Raghunathan, Suchi
Tank, Pratik
Bhadada, Shraddha
Patel, Bhoomika
author_facet Raghunathan, Suchi
Tank, Pratik
Bhadada, Shraddha
Patel, Bhoomika
author_sort Raghunathan, Suchi
collection PubMed
description We have evaluated the effect of buspirone (1.5 mg/kg/day, p.o.) type 1 diabetes induced cardiovascular complications induced by streptozotocin (STZ, 45 mg/kg, i.v.) in Wistar rats. Various biochemical, cardiovascular, and hemodynamic parameters were measured at the end of 8 weeks of treatment. STZ produced significant hyperglycaemia, hypoinsulinemia, and dyslipidemia, which was prevented by buspirone treatment. STZ produced increase in serum creatinine, urea, lactate dehydrogenase, creatinine kinase, and C-reactive protein levels and treatment with buspirone produced reduction in these levels. STZ produced increase in cardiac and LV hypertrophy index, LV/RV ratio, and LV collagen, which were decreased by buspirone treatment. Buspirone also prevented STZ induced hemodynamic alterations and oxidative stress. These results were further supported by histopathological studies in which buspirone showed marked reduction in fibrosis and cardiac fiber disarray. In conclusion, our data suggests that buspirone is beneficial as an antidiabetic agent in type 1 diabetes mellitus and also prevents its cardiac complications.
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spelling pubmed-39158962014-02-23 Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications Raghunathan, Suchi Tank, Pratik Bhadada, Shraddha Patel, Bhoomika Biomed Res Int Research Article We have evaluated the effect of buspirone (1.5 mg/kg/day, p.o.) type 1 diabetes induced cardiovascular complications induced by streptozotocin (STZ, 45 mg/kg, i.v.) in Wistar rats. Various biochemical, cardiovascular, and hemodynamic parameters were measured at the end of 8 weeks of treatment. STZ produced significant hyperglycaemia, hypoinsulinemia, and dyslipidemia, which was prevented by buspirone treatment. STZ produced increase in serum creatinine, urea, lactate dehydrogenase, creatinine kinase, and C-reactive protein levels and treatment with buspirone produced reduction in these levels. STZ produced increase in cardiac and LV hypertrophy index, LV/RV ratio, and LV collagen, which were decreased by buspirone treatment. Buspirone also prevented STZ induced hemodynamic alterations and oxidative stress. These results were further supported by histopathological studies in which buspirone showed marked reduction in fibrosis and cardiac fiber disarray. In conclusion, our data suggests that buspirone is beneficial as an antidiabetic agent in type 1 diabetes mellitus and also prevents its cardiac complications. Hindawi Publishing Corporation 2014 2014-01-20 /pmc/articles/PMC3915896/ /pubmed/24563867 http://dx.doi.org/10.1155/2014/948427 Text en Copyright © 2014 Suchi Raghunathan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Raghunathan, Suchi
Tank, Pratik
Bhadada, Shraddha
Patel, Bhoomika
Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
title Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
title_full Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
title_fullStr Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
title_full_unstemmed Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
title_short Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications
title_sort evaluation of buspirone on streptozotocin induced type 1 diabetes and its associated complications
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915896/
https://www.ncbi.nlm.nih.gov/pubmed/24563867
http://dx.doi.org/10.1155/2014/948427
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