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The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms

BACKGROUND: The dipeptidyl peptidase-4 inhibitor sitagliptin, a new anti-diabetic medicine, is effective in treating type 2 diabetes mellitus by increasing the activation and duration of action of glucagon-like peptide-1. Since atherosclerosis is the main pathological feature of diabetic cardiovascu...

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Detalles Bibliográficos
Autores principales:	Zeng, Yanmei, Li, Chenzhong, Guan, Meiping, Zheng, Zongji, Li, Jingjing, Xu, Wenwei, Wang, Ling, He, Feiying, Xue, Yaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916068/ https://www.ncbi.nlm.nih.gov/pubmed/24490809 http://dx.doi.org/10.1186/1475-2840-13-32

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