Cargando…
Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response t...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916121/ https://www.ncbi.nlm.nih.gov/pubmed/24283209 http://dx.doi.org/10.1111/jcmm.12167 |
_version_ | 1782302669598097408 |
---|---|
author | Vignjević, Sanja Budeč, Mirela Marković, Dragana Đikić, Dragoslava Mitrović, Olivera Mojsilović, Slavko Đurić, Sanja Vranješ Koko, Vesna Čokić, Bojana Beleslin Čokić, Vladan Jovčić, Gordana |
author_facet | Vignjević, Sanja Budeč, Mirela Marković, Dragana Đikić, Dragoslava Mitrović, Olivera Mojsilović, Slavko Đurić, Sanja Vranješ Koko, Vesna Čokić, Bojana Beleslin Čokić, Vladan Jovčić, Gordana |
author_sort | Vignjević, Sanja |
collection | PubMed |
description | Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response to stressful stimuli, and emerging evidence suggests that inappropriate activation of stress erythropoiesis may predispose to leukaemic transformation. We used a mouse model to study the influence of chronic psychological stress on erythropoiesis in the spleen and to investigate potential mediators of observed effects. Adult mice were subjected to 2 hrs daily restraint stress for 7 or 14 consecutive days. Our results showed that chronic exposure to restraint stress decreased the concentration of haemoglobin in the blood, elevated circulating levels of erythropoietin and corticosterone, and resulted in markedly increased number of erythroid progenitors and precursors in the spleen. Western blot analysis revealed significantly decreased expression of both erythropoietin receptor and glucocorticoid receptor in the spleen of restrained mice. Furthermore, chronic stress enhanced the expression of stem cell factor receptor in the red pulp. Moreover, chronically stressed animals exhibited significantly increased expression of bone morphogenetic protein 4 (BMP4) in the red pulp as well as substantially enhanced mRNA expression levels of its receptors in the spleen. These findings demonstrate for the first time that chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis and leads to the prolonged activation of stress erythropoiesis pathways. Prolonged activation of these pathways along with an excessive production of immature erythroid cells may predispose chronically stressed subjects to a higher risk of leukaemic transformation. |
format | Online Article Text |
id | pubmed-3916121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39161212014-12-03 Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis Vignjević, Sanja Budeč, Mirela Marković, Dragana Đikić, Dragoslava Mitrović, Olivera Mojsilović, Slavko Đurić, Sanja Vranješ Koko, Vesna Čokić, Bojana Beleslin Čokić, Vladan Jovčić, Gordana J Cell Mol Med Original Articles Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response to stressful stimuli, and emerging evidence suggests that inappropriate activation of stress erythropoiesis may predispose to leukaemic transformation. We used a mouse model to study the influence of chronic psychological stress on erythropoiesis in the spleen and to investigate potential mediators of observed effects. Adult mice were subjected to 2 hrs daily restraint stress for 7 or 14 consecutive days. Our results showed that chronic exposure to restraint stress decreased the concentration of haemoglobin in the blood, elevated circulating levels of erythropoietin and corticosterone, and resulted in markedly increased number of erythroid progenitors and precursors in the spleen. Western blot analysis revealed significantly decreased expression of both erythropoietin receptor and glucocorticoid receptor in the spleen of restrained mice. Furthermore, chronic stress enhanced the expression of stem cell factor receptor in the red pulp. Moreover, chronically stressed animals exhibited significantly increased expression of bone morphogenetic protein 4 (BMP4) in the red pulp as well as substantially enhanced mRNA expression levels of its receptors in the spleen. These findings demonstrate for the first time that chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis and leads to the prolonged activation of stress erythropoiesis pathways. Prolonged activation of these pathways along with an excessive production of immature erythroid cells may predispose chronically stressed subjects to a higher risk of leukaemic transformation. Blackwell Publishing Ltd 2014-01 2013-11-27 /pmc/articles/PMC3916121/ /pubmed/24283209 http://dx.doi.org/10.1111/jcmm.12167 Text en Copyright © 2014 John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Vignjević, Sanja Budeč, Mirela Marković, Dragana Đikić, Dragoslava Mitrović, Olivera Mojsilović, Slavko Đurić, Sanja Vranješ Koko, Vesna Čokić, Bojana Beleslin Čokić, Vladan Jovčić, Gordana Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis |
title | Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis |
title_full | Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis |
title_fullStr | Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis |
title_full_unstemmed | Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis |
title_short | Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis |
title_sort | chronic psychological stress activates bmp4-dependent extramedullary erythropoiesis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916121/ https://www.ncbi.nlm.nih.gov/pubmed/24283209 http://dx.doi.org/10.1111/jcmm.12167 |
work_keys_str_mv | AT vignjevicsanja chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT budecmirela chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT markovicdragana chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT đikicdragoslava chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT mitrovicolivera chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT mojsilovicslavko chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT đuricsanjavranjes chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT kokovesna chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT cokicbojanabeleslin chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT cokicvladan chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis AT jovcicgordana chronicpsychologicalstressactivatesbmp4dependentextramedullaryerythropoiesis |