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Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis

Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response t...

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Autores principales: Vignjević, Sanja, Budeč, Mirela, Marković, Dragana, Đikić, Dragoslava, Mitrović, Olivera, Mojsilović, Slavko, Đurić, Sanja Vranješ, Koko, Vesna, Čokić, Bojana Beleslin, Čokić, Vladan, Jovčić, Gordana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916121/
https://www.ncbi.nlm.nih.gov/pubmed/24283209
http://dx.doi.org/10.1111/jcmm.12167
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author Vignjević, Sanja
Budeč, Mirela
Marković, Dragana
Đikić, Dragoslava
Mitrović, Olivera
Mojsilović, Slavko
Đurić, Sanja Vranješ
Koko, Vesna
Čokić, Bojana Beleslin
Čokić, Vladan
Jovčić, Gordana
author_facet Vignjević, Sanja
Budeč, Mirela
Marković, Dragana
Đikić, Dragoslava
Mitrović, Olivera
Mojsilović, Slavko
Đurić, Sanja Vranješ
Koko, Vesna
Čokić, Bojana Beleslin
Čokić, Vladan
Jovčić, Gordana
author_sort Vignjević, Sanja
collection PubMed
description Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response to stressful stimuli, and emerging evidence suggests that inappropriate activation of stress erythropoiesis may predispose to leukaemic transformation. We used a mouse model to study the influence of chronic psychological stress on erythropoiesis in the spleen and to investigate potential mediators of observed effects. Adult mice were subjected to 2 hrs daily restraint stress for 7 or 14 consecutive days. Our results showed that chronic exposure to restraint stress decreased the concentration of haemoglobin in the blood, elevated circulating levels of erythropoietin and corticosterone, and resulted in markedly increased number of erythroid progenitors and precursors in the spleen. Western blot analysis revealed significantly decreased expression of both erythropoietin receptor and glucocorticoid receptor in the spleen of restrained mice. Furthermore, chronic stress enhanced the expression of stem cell factor receptor in the red pulp. Moreover, chronically stressed animals exhibited significantly increased expression of bone morphogenetic protein 4 (BMP4) in the red pulp as well as substantially enhanced mRNA expression levels of its receptors in the spleen. These findings demonstrate for the first time that chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis and leads to the prolonged activation of stress erythropoiesis pathways. Prolonged activation of these pathways along with an excessive production of immature erythroid cells may predispose chronically stressed subjects to a higher risk of leukaemic transformation.
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spelling pubmed-39161212014-12-03 Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis Vignjević, Sanja Budeč, Mirela Marković, Dragana Đikić, Dragoslava Mitrović, Olivera Mojsilović, Slavko Đurić, Sanja Vranješ Koko, Vesna Čokić, Bojana Beleslin Čokić, Vladan Jovčić, Gordana J Cell Mol Med Original Articles Psychological stress affects different physiological processes including haematopoiesis. However, erythropoietic effects of chronic psychological stress remain largely unknown. The adult spleen contains a distinct microenvironment favourable for rapid expansion of erythroid progenitors in response to stressful stimuli, and emerging evidence suggests that inappropriate activation of stress erythropoiesis may predispose to leukaemic transformation. We used a mouse model to study the influence of chronic psychological stress on erythropoiesis in the spleen and to investigate potential mediators of observed effects. Adult mice were subjected to 2 hrs daily restraint stress for 7 or 14 consecutive days. Our results showed that chronic exposure to restraint stress decreased the concentration of haemoglobin in the blood, elevated circulating levels of erythropoietin and corticosterone, and resulted in markedly increased number of erythroid progenitors and precursors in the spleen. Western blot analysis revealed significantly decreased expression of both erythropoietin receptor and glucocorticoid receptor in the spleen of restrained mice. Furthermore, chronic stress enhanced the expression of stem cell factor receptor in the red pulp. Moreover, chronically stressed animals exhibited significantly increased expression of bone morphogenetic protein 4 (BMP4) in the red pulp as well as substantially enhanced mRNA expression levels of its receptors in the spleen. These findings demonstrate for the first time that chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis and leads to the prolonged activation of stress erythropoiesis pathways. Prolonged activation of these pathways along with an excessive production of immature erythroid cells may predispose chronically stressed subjects to a higher risk of leukaemic transformation. Blackwell Publishing Ltd 2014-01 2013-11-27 /pmc/articles/PMC3916121/ /pubmed/24283209 http://dx.doi.org/10.1111/jcmm.12167 Text en Copyright © 2014 John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Vignjević, Sanja
Budeč, Mirela
Marković, Dragana
Đikić, Dragoslava
Mitrović, Olivera
Mojsilović, Slavko
Đurić, Sanja Vranješ
Koko, Vesna
Čokić, Bojana Beleslin
Čokić, Vladan
Jovčić, Gordana
Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
title Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
title_full Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
title_fullStr Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
title_full_unstemmed Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
title_short Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis
title_sort chronic psychological stress activates bmp4-dependent extramedullary erythropoiesis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916121/
https://www.ncbi.nlm.nih.gov/pubmed/24283209
http://dx.doi.org/10.1111/jcmm.12167
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