Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts

Lung fibrosis is characterized by vascular leakage and myofibroblast recruitment, and both phenomena are mediated by lysophosphatidic acid (LPA) via its type-1 receptor (LPA1). Following lung damage, the accumulated myofibroblasts activate and secrete excessive extracellular matrix (ECM), and form f...

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Detalles Bibliográficos
Autores principales: Tang, Na, Zhao, Yanxia, Feng, Ruopeng, Liu, Yinan, Wang, Shuling, Wei, Wanguo, Ding, Qiang, An, Michael (Songzhu), Wen, Jinhua, Li, Lingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916127/
https://www.ncbi.nlm.nih.gov/pubmed/24251962
http://dx.doi.org/10.1111/jcmm.12178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916127/
https://www.ncbi.nlm.nih.gov/pubmed/24251962
http://dx.doi.org/10.1111/jcmm.12178

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