Activity of the Adrenergic Nerve System in the Airways Permeability of Healthy Persons

OBJECTIVE: In this work, role of the adrenergic nerve system (alpha(1) and beta(2)) in adjustment of the bronchomotor tonus in healthy people was researched. METHODS: Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines – Asema. RESULTS: Results gained shows that following the blockade of beta-(2) adrenergic receptor with Propranolol (20 mg–aerosol), stimulation of alpha adrenergic receptor with Oxedrine (120 mg-aerosol) and blockage of these receptors with Tolazoline (20 mg-aerosol), does not change significantly the bronchomotor tonus of the tracheobronchial tree (p > 0.1). Meanwhile, stimulation of the beta(-2) adrenergic receptor with Hexoprenaline (2 inh × 0.2 mg) is associated with a significant increase of the peripheral resistance of the airways (p < 0.01). CONCLUSION: This suggests that the activity of the alpha(1)-adrenergic receptor, unlike the activity of the beta(2)-adrenergic receptor in the healthy people smooth musculature, is not significant and as such is insufficient to oppose to the tonic activities of the cholinergic system.