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Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

The accumulation of somatic mitochondrial DNA (mtDNA) mutations is implicated in aging and common diseases of the elderly, including cancer and neurodegenerative disease. However, the mechanisms that influence the frequency of somatic mtDNA mutations are poorly understood. To develop a simple invert...

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Detalles Bibliográficos
Autores principales:	Itsara, Leslie S., Kennedy, Scott R., Fox, Edward J., Yu, Selina, Hewitt, Joshua J., Sanchez-Contreras, Monica, Cardozo-Pelaez, Fernando, Pallanck, Leo J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916223/ https://www.ncbi.nlm.nih.gov/pubmed/24516391 http://dx.doi.org/10.1371/journal.pgen.1003974

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