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NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly
Biogenesis of mammalian mitochondrial ribosomes requires a concerted maturation of both the small (SSU) and large subunit (LSU). We demonstrate here that the m(5)C methyltransferase NSUN4, which forms a complex with MTERF4, is essential in mitochondrial ribosomal biogenesis as mitochondrial translat...
Autores principales: | Metodiev, Metodi Dimitrov, Spåhr, Henrik, Loguercio Polosa, Paola, Meharg, Caroline, Becker, Christian, Altmueller, Janine, Habermann, Bianca, Larsson, Nils-Göran, Ruzzenente, Benedetta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916286/ https://www.ncbi.nlm.nih.gov/pubmed/24516400 http://dx.doi.org/10.1371/journal.pgen.1004110 |
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