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Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today?
The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex pathophysiologic response to an insult such as infection, trauma, burns, pancreatitis, or a variety of other injuries came from a 1991 consensus conference charged with the task of developing an easy-to-apply set...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Landes Bioscience
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916374/ https://www.ncbi.nlm.nih.gov/pubmed/24280933 http://dx.doi.org/10.4161/viru.27135 |
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author | Balk, Robert A |
author_facet | Balk, Robert A |
author_sort | Balk, Robert A |
collection | PubMed |
description | The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex pathophysiologic response to an insult such as infection, trauma, burns, pancreatitis, or a variety of other injuries came from a 1991 consensus conference charged with the task of developing an easy-to-apply set of clinical parameters to aid in the early identification of potential candidates to enter into clinical trials to evaluate new treatments for sepsis. There was recognition that a diverse group of injuries produced a common inflammatory response in the host and provided attractive targets for new anti-inflammatory molecules designed to prevent further propagation and/or provide specific treatment. Effective application of these new anti-inflammatory strategies necessitated identification of early clinical markers that could be assessed in real-time and were likely to define a population of patients that would have a beneficial response to the targeted intervention. It was felt that early clinical manifestations might be more readily available to clinicians than more sophisticated and specific assays for inflammatory substances that were systemically released by the network of injurious inflammatory events. Therefore, the early definition of a systemic inflammatory response syndrome (SIRS) was built upon a foundation of basic clinical and laboratory abnormalities that were readily available in almost all clinical settings. With further refinement, it was hoped, that this definition would have a high degree of sensitivity, coupled with a reasonable degree of specificity. This manuscript reviews the derivation, application, utilization, potential benefits, and speculation regarding the future of the SIRS definition. |
format | Online Article Text |
id | pubmed-3916374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-39163742014-03-06 Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today? Balk, Robert A Virulence Review The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex pathophysiologic response to an insult such as infection, trauma, burns, pancreatitis, or a variety of other injuries came from a 1991 consensus conference charged with the task of developing an easy-to-apply set of clinical parameters to aid in the early identification of potential candidates to enter into clinical trials to evaluate new treatments for sepsis. There was recognition that a diverse group of injuries produced a common inflammatory response in the host and provided attractive targets for new anti-inflammatory molecules designed to prevent further propagation and/or provide specific treatment. Effective application of these new anti-inflammatory strategies necessitated identification of early clinical markers that could be assessed in real-time and were likely to define a population of patients that would have a beneficial response to the targeted intervention. It was felt that early clinical manifestations might be more readily available to clinicians than more sophisticated and specific assays for inflammatory substances that were systemically released by the network of injurious inflammatory events. Therefore, the early definition of a systemic inflammatory response syndrome (SIRS) was built upon a foundation of basic clinical and laboratory abnormalities that were readily available in almost all clinical settings. With further refinement, it was hoped, that this definition would have a high degree of sensitivity, coupled with a reasonable degree of specificity. This manuscript reviews the derivation, application, utilization, potential benefits, and speculation regarding the future of the SIRS definition. Landes Bioscience 2014-01-01 2013-11-13 /pmc/articles/PMC3916374/ /pubmed/24280933 http://dx.doi.org/10.4161/viru.27135 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Balk, Robert A Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today? |
title | Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today? |
title_full | Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today? |
title_fullStr | Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today? |
title_full_unstemmed | Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today? |
title_short | Systemic inflammatory response syndrome (SIRS): Where did it come from and is it still relevant today? |
title_sort | systemic inflammatory response syndrome (sirs): where did it come from and is it still relevant today? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916374/ https://www.ncbi.nlm.nih.gov/pubmed/24280933 http://dx.doi.org/10.4161/viru.27135 |
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