Overexpression of Cyclooxygenase-2 in Malignant Peripheral Nerve Sheath Tumor and Selective Cyclooxygenase-2 Inhibitor-Induced Apoptosis by Activating Caspases in Human Malignant Peripheral Nerve Sheath Tumor Cells

BACKGROUND: Cyclooxygenase-2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostanoids, and its activation is associated with carcinogenesis as well as inflammation. The antitumor effect of selective COX-2 inhibitors has been noted in various malignancies. Malignant peripheral ner...

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Detalles Bibliográficos
Autores principales: Hakozaki, Michiyuki, Tajino, Takahiro, Konno, Shinichi, Kikuchi, Shinichi, Yamada, Hitoshi, Yanagisawa, Michiro, Nishida, Jun, Nagasawa, Hiroyuki, Tsuchiya, Takashi, Ogose, Akira, Abe, Masafumi, Hojo, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916395/
https://www.ncbi.nlm.nih.gov/pubmed/24516579
http://dx.doi.org/10.1371/journal.pone.0088035

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