Substrate-Induced Unfolding of Protein Disulfide Isomerase Displaces the Cholera Toxin A1 Subunit from Its Holotoxin

To generate a cytopathic effect, the catalytic A1 subunit of cholera toxin (CT) must be separated from the rest of the toxin. Protein disulfide isomerase (PDI) is thought to mediate CT disassembly by acting as a redox-driven chaperone that actively unfolds the CTA1 subunit. Here, we show that PDI it...

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Detalles Bibliográficos
Autores principales: Taylor, Michael, Burress, Helen, Banerjee, Tuhina, Ray, Supriyo, Curtis, David, Tatulian, Suren A., Teter, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916401/
https://www.ncbi.nlm.nih.gov/pubmed/24516389
http://dx.doi.org/10.1371/journal.ppat.1003925

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