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An AAV Vector-Mediated Gene Delivery Approach Facilitates Reconstitution of Functional Human CD8(+) T Cells in Mice

In the present study, a novel adeno-associated virus (AAV) vector-mediated gene delivery approach was taken to improve the reconstitution of functional CD8(+) T cells in humanized mice, thereby mimicking the human immune system (HIS). Human genes encoding HLA-A2 and selected human cytokines (A2/hucy...

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Detalles Bibliográficos
Autores principales:	Huang, Jing, Li, Xiangming, Coelho-dos-Reis, Jordana G. A., Wilson, James M., Tsuji, Moriya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916402/ https://www.ncbi.nlm.nih.gov/pubmed/24516613 http://dx.doi.org/10.1371/journal.pone.0088205

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