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Use of Quantitative Mass Spectrometric Analysis to Elucidate the Mechanisms of Phospho-priming and Auto-activation of the Checkpoint Kinase Rad53 in Vivo

The cell cycle checkpoint kinases play central roles in the genome maintenance of eukaryotes. Activation of the yeast checkpoint kinase Rad53 involves Rad9 or Mrc1 adaptor-mediated phospho-priming by Mec1 kinase, followed by auto-activating phosphorylation within its activation loop. However, the me...

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Detalles Bibliográficos
Autores principales:	Chen, Eric S.-W., Hoch, Nicolas C., Wang, Shun-Chang, Pellicioli, Achille, Heierhorst, Jörg, Tsai, Ming-Daw
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916653/ https://www.ncbi.nlm.nih.gov/pubmed/24302356 http://dx.doi.org/10.1074/mcp.M113.034058

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