The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits

Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of thes...

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Autores principales: Hitzemann, Robert, Bottomly, Daniel, Iancu, Ovidiu, Buck, Kari, Wilmot, Beth, Mooney, Michael, Searles, Robert, Zheng, Christina, Belknap, John, Crabbe, John, McWeeney, Shannon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916704/
https://www.ncbi.nlm.nih.gov/pubmed/24374554
http://dx.doi.org/10.1007/s00335-013-9495-6
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author Hitzemann, Robert
Bottomly, Daniel
Iancu, Ovidiu
Buck, Kari
Wilmot, Beth
Mooney, Michael
Searles, Robert
Zheng, Christina
Belknap, John
Crabbe, John
McWeeney, Shannon
author_facet Hitzemann, Robert
Bottomly, Daniel
Iancu, Ovidiu
Buck, Kari
Wilmot, Beth
Mooney, Michael
Searles, Robert
Zheng, Christina
Belknap, John
Crabbe, John
McWeeney, Shannon
author_sort Hitzemann, Robert
collection PubMed
description Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.
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spelling pubmed-39167042014-02-13 The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits Hitzemann, Robert Bottomly, Daniel Iancu, Ovidiu Buck, Kari Wilmot, Beth Mooney, Michael Searles, Robert Zheng, Christina Belknap, John Crabbe, John McWeeney, Shannon Mamm Genome Article Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning. Springer US 2013-12-31 2014 /pmc/articles/PMC3916704/ /pubmed/24374554 http://dx.doi.org/10.1007/s00335-013-9495-6 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Hitzemann, Robert
Bottomly, Daniel
Iancu, Ovidiu
Buck, Kari
Wilmot, Beth
Mooney, Michael
Searles, Robert
Zheng, Christina
Belknap, John
Crabbe, John
McWeeney, Shannon
The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
title The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
title_full The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
title_fullStr The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
title_full_unstemmed The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
title_short The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
title_sort genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916704/
https://www.ncbi.nlm.nih.gov/pubmed/24374554
http://dx.doi.org/10.1007/s00335-013-9495-6
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