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Molybdenum metabolism in plants and crosstalk to iron
In the form of molybdate the transition metal molybdenum is essential for plants as it is required by a number of enzymes that catalyze key reactions in nitrogen assimilation, purine degradation, phytohormone synthesis, and sulfite detoxification. However, molybdate itself is biologically inactive a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916724/ https://www.ncbi.nlm.nih.gov/pubmed/24570679 http://dx.doi.org/10.3389/fpls.2014.00028 |
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author | Bittner, Florian |
author_facet | Bittner, Florian |
author_sort | Bittner, Florian |
collection | PubMed |
description | In the form of molybdate the transition metal molybdenum is essential for plants as it is required by a number of enzymes that catalyze key reactions in nitrogen assimilation, purine degradation, phytohormone synthesis, and sulfite detoxification. However, molybdate itself is biologically inactive and needs to be complexed by a specific organic pterin in order to serve as a permanently bound prosthetic group, the molybdenum cofactor, for the socalled molybdo-enyzmes. While the synthesis of molybdenum cofactor has been intensively studied, only little is known about the uptake of molybdate by the roots, its transport to the shoot and its allocation and storage within the cell. Yet, recent evidence indicates that intracellular molybdate levels are tightly controlled by molybdate transporters, in particular during plant development. Moreover, a tight connection between molybdenum and iron metabolisms is presumed because (i) uptake mechanisms for molybdate and iron affect each other, (ii) most molybdo-enzymes do also require iron-containing redox groups such as iron-sulfur clusters or heme, (iii) molybdenum metabolism has recruited mechanisms typical for iron-sulfur cluster synthesis, and (iv) both molybdenum cofactor synthesis and extramitochondrial iron-sulfur proteins involve the function of a specific mitochondrial ABC-type transporter. |
format | Online Article Text |
id | pubmed-3916724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39167242014-02-25 Molybdenum metabolism in plants and crosstalk to iron Bittner, Florian Front Plant Sci Plant Science In the form of molybdate the transition metal molybdenum is essential for plants as it is required by a number of enzymes that catalyze key reactions in nitrogen assimilation, purine degradation, phytohormone synthesis, and sulfite detoxification. However, molybdate itself is biologically inactive and needs to be complexed by a specific organic pterin in order to serve as a permanently bound prosthetic group, the molybdenum cofactor, for the socalled molybdo-enyzmes. While the synthesis of molybdenum cofactor has been intensively studied, only little is known about the uptake of molybdate by the roots, its transport to the shoot and its allocation and storage within the cell. Yet, recent evidence indicates that intracellular molybdate levels are tightly controlled by molybdate transporters, in particular during plant development. Moreover, a tight connection between molybdenum and iron metabolisms is presumed because (i) uptake mechanisms for molybdate and iron affect each other, (ii) most molybdo-enzymes do also require iron-containing redox groups such as iron-sulfur clusters or heme, (iii) molybdenum metabolism has recruited mechanisms typical for iron-sulfur cluster synthesis, and (iv) both molybdenum cofactor synthesis and extramitochondrial iron-sulfur proteins involve the function of a specific mitochondrial ABC-type transporter. Frontiers Media S.A. 2014-02-07 /pmc/articles/PMC3916724/ /pubmed/24570679 http://dx.doi.org/10.3389/fpls.2014.00028 Text en Copyright © 2014 Bittner. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Bittner, Florian Molybdenum metabolism in plants and crosstalk to iron |
title | Molybdenum metabolism in plants and crosstalk to iron |
title_full | Molybdenum metabolism in plants and crosstalk to iron |
title_fullStr | Molybdenum metabolism in plants and crosstalk to iron |
title_full_unstemmed | Molybdenum metabolism in plants and crosstalk to iron |
title_short | Molybdenum metabolism in plants and crosstalk to iron |
title_sort | molybdenum metabolism in plants and crosstalk to iron |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916724/ https://www.ncbi.nlm.nih.gov/pubmed/24570679 http://dx.doi.org/10.3389/fpls.2014.00028 |
work_keys_str_mv | AT bittnerflorian molybdenummetabolisminplantsandcrosstalktoiron |