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Bright/Arid3A Acts as a Barrier to Somatic Cell Reprogramming through Direct Regulation of Oct4, Sox2, and Nanog

We show here that singular loss of the Bright/Arid3A transcription factor leads to reprograming of mouse embryonic fibroblasts (MEFs) and enhancement of standard four-factor (4F) reprogramming. Bright-deficient MEFs bypass senescence and, under standard embryonic stem cell (ESC) culture conditions,...

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Detalles Bibliográficos
Autores principales:	Popowski, Melissa, Templeton, Troy D., Lee, Bum-Kyu, Rhee, Catherine, Li, He, Miner, Cathrine, Dekker, Joseph D., Orlanski, Shari, Bergman, Yehudit, Iyer, Vishwanath R., Webb, Carol F., Tucker, Haley
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916758/ https://www.ncbi.nlm.nih.gov/pubmed/24511468 http://dx.doi.org/10.1016/j.stemcr.2013.12.002

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