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Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors
Transitioning to human trials from pre-clinical models resulted in the emergence of inhibitory AAV vector immune responses which has become a hurdle for sustained correction. Early animal studies did not predict the full range of host immunity to the AAV vector in human studies. While pre-existing a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916775/ https://www.ncbi.nlm.nih.gov/pubmed/24570676 http://dx.doi.org/10.3389/fimmu.2014.00028 |