Pre-Clinical Assessment of Immune Responses to Adeno-Associated Virus (AAV) Vectors

Transitioning to human trials from pre-clinical models resulted in the emergence of inhibitory AAV vector immune responses which has become a hurdle for sustained correction. Early animal studies did not predict the full range of host immunity to the AAV vector in human studies. While pre-existing a...

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Detalles Bibliográficos
Autores principales: Basner-Tschakarjan, Etiena, Bijjiga, Enoch, Martino, Ashley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916775/
https://www.ncbi.nlm.nih.gov/pubmed/24570676
http://dx.doi.org/10.3389/fimmu.2014.00028

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