Cargando…

Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial

Iron deficiency anaemia (IDA) is the most common nutritional deficiency in the world including developed and developing countries. Despite intensive efforts to improve the quality of life of rural and aboriginal communities in Malaysia, anaemia and IDA are still major public health problems in these...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Mekhlafi, Hesham M., Al-Zabedi, Ebtesam M., Al-Maktari, Mohamed T., Atroosh, Wahib M., Al-Delaimy, Ahmed K., Moktar, Norhayati, Sallam, Atiya A., Abdullah, Wan Ariffin, Jani, Rohana, Surin, Johari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916855/
https://www.ncbi.nlm.nih.gov/pubmed/24384995
http://dx.doi.org/10.3390/nu6010190
_version_ 1782302772976156672
author Al-Mekhlafi, Hesham M.
Al-Zabedi, Ebtesam M.
Al-Maktari, Mohamed T.
Atroosh, Wahib M.
Al-Delaimy, Ahmed K.
Moktar, Norhayati
Sallam, Atiya A.
Abdullah, Wan Ariffin
Jani, Rohana
Surin, Johari
author_facet Al-Mekhlafi, Hesham M.
Al-Zabedi, Ebtesam M.
Al-Maktari, Mohamed T.
Atroosh, Wahib M.
Al-Delaimy, Ahmed K.
Moktar, Norhayati
Sallam, Atiya A.
Abdullah, Wan Ariffin
Jani, Rohana
Surin, Johari
author_sort Al-Mekhlafi, Hesham M.
collection PubMed
description Iron deficiency anaemia (IDA) is the most common nutritional deficiency in the world including developed and developing countries. Despite intensive efforts to improve the quality of life of rural and aboriginal communities in Malaysia, anaemia and IDA are still major public health problems in these communities particularly among children. A randomized, double-blind, placebo-controlled trial was conducted on 250 Orang Asli (aboriginal) schoolchildren in Malaysia to investigate the effects of a single high-dose of vitamin A supplementation (200,000 IU) on iron status indices, anaemia and IDA status. The effect of the supplement was assessed after 3 months of receiving the supplements; after a complete 3-day deworming course of 400 mg/day of albendazole tablets. The prevalence of anaemia was found to be high: 48.5% (95% CI = 42.3, 54.8). Moreover, 34% (95% CI = 28.3, 40.2) of the children had IDA, which accounted for 70.1% of the anaemic cases. The findings showed that the reduction in serum ferritin level and the increments in haemoglobin, serum iron and transferrin saturation were found to be significant among children allocated to the vitamin A group compared to those allocated to the placebo group (p < 0.01). Moreover, a significant reduction in the prevalence of IDA by almost 22% than prevalence at baseline was reported among children in the vitamin A group compared with only 2.3% reduction among children in the placebo group. In conclusion, vitamin A supplementation showed a significant impact on iron status indices and IDA among Orang Asli children. Hence, providing vitamin A supplementation and imparting the knowledge related to nutritious food should be considered in the efforts to improve the nutritional and health status of these children as a part of efforts to improve the quality of life in rural and aboriginal communities.
format Online
Article
Text
id pubmed-3916855
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-39168552014-02-07 Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial Al-Mekhlafi, Hesham M. Al-Zabedi, Ebtesam M. Al-Maktari, Mohamed T. Atroosh, Wahib M. Al-Delaimy, Ahmed K. Moktar, Norhayati Sallam, Atiya A. Abdullah, Wan Ariffin Jani, Rohana Surin, Johari Nutrients Article Iron deficiency anaemia (IDA) is the most common nutritional deficiency in the world including developed and developing countries. Despite intensive efforts to improve the quality of life of rural and aboriginal communities in Malaysia, anaemia and IDA are still major public health problems in these communities particularly among children. A randomized, double-blind, placebo-controlled trial was conducted on 250 Orang Asli (aboriginal) schoolchildren in Malaysia to investigate the effects of a single high-dose of vitamin A supplementation (200,000 IU) on iron status indices, anaemia and IDA status. The effect of the supplement was assessed after 3 months of receiving the supplements; after a complete 3-day deworming course of 400 mg/day of albendazole tablets. The prevalence of anaemia was found to be high: 48.5% (95% CI = 42.3, 54.8). Moreover, 34% (95% CI = 28.3, 40.2) of the children had IDA, which accounted for 70.1% of the anaemic cases. The findings showed that the reduction in serum ferritin level and the increments in haemoglobin, serum iron and transferrin saturation were found to be significant among children allocated to the vitamin A group compared to those allocated to the placebo group (p < 0.01). Moreover, a significant reduction in the prevalence of IDA by almost 22% than prevalence at baseline was reported among children in the vitamin A group compared with only 2.3% reduction among children in the placebo group. In conclusion, vitamin A supplementation showed a significant impact on iron status indices and IDA among Orang Asli children. Hence, providing vitamin A supplementation and imparting the knowledge related to nutritious food should be considered in the efforts to improve the nutritional and health status of these children as a part of efforts to improve the quality of life in rural and aboriginal communities. MDPI 2013-12-31 /pmc/articles/PMC3916855/ /pubmed/24384995 http://dx.doi.org/10.3390/nu6010190 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Al-Mekhlafi, Hesham M.
Al-Zabedi, Ebtesam M.
Al-Maktari, Mohamed T.
Atroosh, Wahib M.
Al-Delaimy, Ahmed K.
Moktar, Norhayati
Sallam, Atiya A.
Abdullah, Wan Ariffin
Jani, Rohana
Surin, Johari
Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial
title Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial
title_full Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial
title_fullStr Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial
title_full_unstemmed Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial
title_short Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial
title_sort effects of vitamin a supplementation on iron status indices and iron deficiency anaemia: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916855/
https://www.ncbi.nlm.nih.gov/pubmed/24384995
http://dx.doi.org/10.3390/nu6010190
work_keys_str_mv AT almekhlafiheshamm effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT alzabediebtesamm effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT almaktarimohamedt effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT atrooshwahibm effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT aldelaimyahmedk effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT moktarnorhayati effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT sallamatiyaa effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT abdullahwanariffin effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT janirohana effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial
AT surinjohari effectsofvitaminasupplementationonironstatusindicesandirondeficiencyanaemiaarandomizedcontrolledtrial