Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms

The mechanisms involved in progression from monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) to malignant multiple myeloma (MM) and plasma cell leukemia (PCL) are poorly understood but believed to involve the sequential acquisition of genetic hits. We performed...

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Detalles Bibliográficos
Autores principales: Walker, Brian A, Wardell, Christopher P, Melchor, Lorenzo, Brioli, Annamaria, Johnson, David C, Kaiser, Martin F, Mirabella, Fabio, Lopez-Corral, Lucia, Humphray, Sean, Murray, Lisa, Ross, Mark, Bentley, David, Gutiérrez, Norma C., Garcia-Sanz, Ramón, San Miguel, Jesus, Davies, Faith E, Gonzalez, David, Morgan, Gareth J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916874/
https://www.ncbi.nlm.nih.gov/pubmed/23817176
http://dx.doi.org/10.1038/leu.2013.199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916874/
https://www.ncbi.nlm.nih.gov/pubmed/23817176
http://dx.doi.org/10.1038/leu.2013.199

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