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NLS-RARα Promotes Proliferation and Inhibits Differentiation in HL-60 Cells

A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor α (RARα) and a myeloid gene product called PML. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RARα in early...

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Detalles Bibliográficos
Autores principales:	Hu, Xiu-Xiu, Zhong, Liang, Zhang, Xi, Gao, Yuan-Mei, Liu, Bei-Zhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917113/ https://www.ncbi.nlm.nih.gov/pubmed/24516348 http://dx.doi.org/10.7150/ijms.6518

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