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Periodic paralysis: An unusual presentation of drug-induced hyperkalemia

Hyperkalemia is a life-threatening electrolyte abnormality. The most common cause of hyperkalemia includes renal disease and ingestion of medications. Drug-induced hyperkalemia may develop in patients with underlying renal impairment, disturbed cellular uptake of potassium load, excessive ingestion...

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Autores principales: Agrawal, Poonam, Chopra, Deepti, Patra, Surajeet K., Madaan, Himanshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917171/
https://www.ncbi.nlm.nih.gov/pubmed/24554915
http://dx.doi.org/10.4103/0976-500X.124429
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author Agrawal, Poonam
Chopra, Deepti
Patra, Surajeet K.
Madaan, Himanshu
author_facet Agrawal, Poonam
Chopra, Deepti
Patra, Surajeet K.
Madaan, Himanshu
author_sort Agrawal, Poonam
collection PubMed
description Hyperkalemia is a life-threatening electrolyte abnormality. The most common cause of hyperkalemia includes renal disease and ingestion of medications. Drug-induced hyperkalemia may develop in patients with underlying renal impairment, disturbed cellular uptake of potassium load, excessive ingestion or infusion of potassium-containing substances. We report a case of “drug-induced severe hyperkalemia” presenting as periodic paralysis. A 67-year-old diabetic and hypertensive woman presented to emergency department with the complaint of intermittent episode of inability to walk for the past 5 days. Each episode lasted for 15-20 minutes and was associated with breathlessness and restlessness. There was no family history of periodic paralysis and drug history revealed that the patient was onolmesartan 20 mg per day (for past 2 years), perindopril 4 mg per day (for past 16 months), and torsemide 10 mg/day. On examination patient was found to be conscious, alert, and afebrile. Vitals were normal. Examination of cardiovascular and respiratory system did not reveal any significant finding. Blood report of the patient showed serum K+ level 8.6 mmol/l. All other investigations were within normal limits. A diagnosis of drug-induced hyperkalemia was made. Patient responded well to the symptomatic treatment. To the best of the author's knowledge, this is the first case report of drug-induced hyperkalemia presenting as periodic paralysis.
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spelling pubmed-39171712014-02-19 Periodic paralysis: An unusual presentation of drug-induced hyperkalemia Agrawal, Poonam Chopra, Deepti Patra, Surajeet K. Madaan, Himanshu J Pharmacol Pharmacother Case Report Hyperkalemia is a life-threatening electrolyte abnormality. The most common cause of hyperkalemia includes renal disease and ingestion of medications. Drug-induced hyperkalemia may develop in patients with underlying renal impairment, disturbed cellular uptake of potassium load, excessive ingestion or infusion of potassium-containing substances. We report a case of “drug-induced severe hyperkalemia” presenting as periodic paralysis. A 67-year-old diabetic and hypertensive woman presented to emergency department with the complaint of intermittent episode of inability to walk for the past 5 days. Each episode lasted for 15-20 minutes and was associated with breathlessness and restlessness. There was no family history of periodic paralysis and drug history revealed that the patient was onolmesartan 20 mg per day (for past 2 years), perindopril 4 mg per day (for past 16 months), and torsemide 10 mg/day. On examination patient was found to be conscious, alert, and afebrile. Vitals were normal. Examination of cardiovascular and respiratory system did not reveal any significant finding. Blood report of the patient showed serum K+ level 8.6 mmol/l. All other investigations were within normal limits. A diagnosis of drug-induced hyperkalemia was made. Patient responded well to the symptomatic treatment. To the best of the author's knowledge, this is the first case report of drug-induced hyperkalemia presenting as periodic paralysis. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3917171/ /pubmed/24554915 http://dx.doi.org/10.4103/0976-500X.124429 Text en Copyright: © Journal of Pharmacology and Pharmacotherapeutics http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Agrawal, Poonam
Chopra, Deepti
Patra, Surajeet K.
Madaan, Himanshu
Periodic paralysis: An unusual presentation of drug-induced hyperkalemia
title Periodic paralysis: An unusual presentation of drug-induced hyperkalemia
title_full Periodic paralysis: An unusual presentation of drug-induced hyperkalemia
title_fullStr Periodic paralysis: An unusual presentation of drug-induced hyperkalemia
title_full_unstemmed Periodic paralysis: An unusual presentation of drug-induced hyperkalemia
title_short Periodic paralysis: An unusual presentation of drug-induced hyperkalemia
title_sort periodic paralysis: an unusual presentation of drug-induced hyperkalemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917171/
https://www.ncbi.nlm.nih.gov/pubmed/24554915
http://dx.doi.org/10.4103/0976-500X.124429
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