Cargando…

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

Homeostasis of mammalian cell function strictly depends on balancing oxygen exposure to maintain energy metabolism without producing excessive reactive oxygen species. In vivo, cells in different tissues are exposed to a wide range of oxygen concentrations, and yet in vitro models almost exclusively...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ng, Shengyong, March, Sandra, Galstian, Ani, Hanson, Kirsten, Carvalho, Tânia, Mota, Maria M., Bhatia, Sangeeta N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917242/ https://www.ncbi.nlm.nih.gov/pubmed/24291761 http://dx.doi.org/10.1242/dmm.013490

Ejemplares similares

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro
por: Ng, Shengyong, et al.
Publicado: (2015)

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers
por: Ng, Shengyong, et al.
Publicado: (2017)

Improved isolation of murine hepatocytes for in vitro malaria liver stage studies
por: Gonçalves, Lígia A, et al.
Publicado: (2007)

Host Cell Phosphatidylcholine Is a Key Mediator of Malaria Parasite Survival during Liver Stage Infection
por: Itoe, Maurice A., et al.
Publicado: (2014)

Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis
por: Kaushansky, A, et al.
Publicado: (2013)

Malaria Blood Stage Suppression of Liver Stage Immunity by Dendritic Cells
por: Ocaña-Morgner, Carlos, et al.
Publicado: (2003)

The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage
por: Derbyshire, Emily R., et al.
Publicado: (2011)

Controversies Surrounding the Origin of Hepatocytes in Adult Livers and the in Vitro Generation or Propagation of Hepatocytes
por: Pek, Nicole Min Qian, et al.
Publicado: (2020)

In vitro Liver Zonation of Primary Rat Hepatocytes
por: Tomlinson, Lauren, et al.
Publicado: (2019)

Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development
por: Balasubramanian, Lakshmi, et al.
Publicado: (2020)

Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes
por: van Schaijk, Ben C. L., et al.
Publicado: (2008)

Exosome-Mimetic Nanovesicles from Hepatocytes promote hepatocyte proliferation in vitro and liver regeneration in vivo
por: Wu, Jun-Yi, et al.
Publicado: (2018)

Stress granules and Plasmodium liver stage infection
por: Hanson, Kirsten K., et al.
Publicado: (2013)

Protection from liver-stage malaria is dependent on a fine balance between the number of infected hepatocytes and effector CD8(+) T cells
por: Spencer, Alexandra, et al.
Publicado: (2014)

In vitro culture of isolated primary hepatocytes and stem cell-derived hepatocyte-like cells for liver regeneration
por: Hu, Chenxia, et al.
Publicado: (2015)

Malaria Liver Stage Susceptibility Locus Identified on Mouse Chromosome 17 by Congenic Mapping
por: Gonçalves, Lígia Antunes, et al.
Publicado: (2008)

In Vitro Toxicity of Epigallocatechin Gallate in Rat Liver Mitochondria and Hepatocytes
por: Kucera, Otto, et al.
Publicado: (2015)

The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8(+) T Cells Present in the Liver
por: Spencer, Alexandra J., et al.
Publicado: (2017)

Protective efficacy and safety of liver stage attenuated malaria parasites
por: Kumar, Hirdesh, et al.
Publicado: (2016)

Prevalence of a type-I interferon immune response against malaria liver stage infection
por: Liehl, Peter, et al.
Publicado: (2010)

Protective immunity to liver-stage malaria
por: Holz, Lauren E, et al.
Publicado: (2016)

Establishment of an In Vitro Assay for Assessing the Effects of Drugs on the Liver Stages of Plasmodium vivax Malaria
por: Chattopadhyay, Rana, et al.
Publicado: (2010)

Anti-PCSK9 Treatment Attenuates Liver Fibrosis via Inhibiting Hypoxia-Induced Autophagy in Hepatocytes
por: Ning, Liuxin, et al.
Publicado: (2023)

Variable responses of small and large human hepatocytes to hypoxia and hypoxia/reoxygenation (H–R)
por: Bhogal, Ricky H., et al.
Publicado: (2011)

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease
por: Mesarwi, Omar A., et al.
Publicado: (2016)

Mid-Liver Stage Arrest of Plasmodium falciparum Schizonts in Primary Porcine Hepatocytes
por: van der Boor, Saskia C., et al.
Publicado: (2022)

DRAM is Involved in Hypoxia/Ischemia-Induced Autophagic Apoptosis in Hepatocytes
por: Xu, Jianji, et al.
Publicado: (2019)

Smart mini-cameras
por: Galstian, Tigran
Publicado: (2014)

Smart Mini-Cameras
por: Galstian, Tigran
Publicado: (2013)

Local pulses of electrical potential can induce long-range transient excitations in self-aligned molecular films
por: Dadalyan, T., et al.
Publicado: (2019)

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes
por: Scoon, Whitney A., et al.
Publicado: (2022)

Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures
por: Yang, Annie S. P., et al.
Publicado: (2023)

Effects of oxygen on malaria infection: implications for studying liver-stage malaria
Publicado: (2014)

Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)—In Vitro Testing
por: Tátrai, Péter, et al.
Publicado: (2022)

Inhibitory Effect of TNF-α on Malaria Pre-Erythrocytic Stage Development: Influence of Host Hepatocyte/Parasite Combinations
por: Depinay, Nadya, et al.
Publicado: (2011)

Overexpression of hepatocyte EphA2 enhances liver-stage infection by Plasmodium vivax
por: Chainarin, Sittinont, et al.
Publicado: (2022)

Rapid clearance of malaria circumsporozoite protein (CS) by hepatocytes
Publicado: (1994)

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes
Publicado: (1996)

Plasmodium translocon component EXP2 facilitates hepatocyte invasion
por: Mello-Vieira, João, et al.
Publicado: (2020)

The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes
por: Schaffner, Carlos A, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_eo9eslstbj7rrnh42hklptb03q