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Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis

BACKGROUND: Delay in diagnosis and treatment of perforated appendicitis may cause life-threatening complications.The aim of this study was to determine and compare pre-operative total and direct bilirubin levels incases of simple and perforated acute appendicitis in order to improve the clinical dec...

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Autores principales: Vaziri, Mohammad, Pazouki, Abdolreza, Tamannaie, Zeinab, Maghsoudloo, Farshid, Pishgahroudsari, Mohadeseh, Chaichian, Shahla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917482/
https://www.ncbi.nlm.nih.gov/pubmed/24791119
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author Vaziri, Mohammad
Pazouki, Abdolreza
Tamannaie, Zeinab
Maghsoudloo, Farshid
Pishgahroudsari, Mohadeseh
Chaichian, Shahla
author_facet Vaziri, Mohammad
Pazouki, Abdolreza
Tamannaie, Zeinab
Maghsoudloo, Farshid
Pishgahroudsari, Mohadeseh
Chaichian, Shahla
author_sort Vaziri, Mohammad
collection PubMed
description BACKGROUND: Delay in diagnosis and treatment of perforated appendicitis may cause life-threatening complications.The aim of this study was to determine and compare pre-operative total and direct bilirubin levels incases of simple and perforated acute appendicitis in order to improve the clinical decision making. METHODS: This prospective observational study included eighty patients who underwent open appendectomy,during a one-year period from March 2010 to March 2011 in the surgical department of Hazrat-e-Rasool AkramHospital, an academic teaching hospital in Tehran- Iran. Pre-operative total and direct levels of bilirubin werecompared in two groups of histologically proved appendicitis (simple and perforated), each including 40 patients. RESULTS: Eighty patients who underwent open appendectomy including 70% men and 30% women with a meanage of 34±11 years in Group I (perforated appendicitis) and 47.5% women and 52.5% men with a mean age of33±14 in Group II (simple appendicitis) were included in this study. The mean bilirubin levels were higher forpatients with perforated acute appendicitis compared to those with a non-perforated simple appendicitis(1.04±05 mg/dl vs 0.7±0.1 mg/dl) and this difference is highly significant (p<0.01). CONCLUSION: Assessment of preoperative total bilirubin is useful for the differential diagnosis of perforatedversus acute simple appendicitis and total bilirubin should be used as an independent parameter in the early diagnosisof appendix perforation
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spelling pubmed-39174822014-05-01 Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis Vaziri, Mohammad Pazouki, Abdolreza Tamannaie, Zeinab Maghsoudloo, Farshid Pishgahroudsari, Mohadeseh Chaichian, Shahla Med J Islam Repub Iran Original Article BACKGROUND: Delay in diagnosis and treatment of perforated appendicitis may cause life-threatening complications.The aim of this study was to determine and compare pre-operative total and direct bilirubin levels incases of simple and perforated acute appendicitis in order to improve the clinical decision making. METHODS: This prospective observational study included eighty patients who underwent open appendectomy,during a one-year period from March 2010 to March 2011 in the surgical department of Hazrat-e-Rasool AkramHospital, an academic teaching hospital in Tehran- Iran. Pre-operative total and direct levels of bilirubin werecompared in two groups of histologically proved appendicitis (simple and perforated), each including 40 patients. RESULTS: Eighty patients who underwent open appendectomy including 70% men and 30% women with a meanage of 34±11 years in Group I (perforated appendicitis) and 47.5% women and 52.5% men with a mean age of33±14 in Group II (simple appendicitis) were included in this study. The mean bilirubin levels were higher forpatients with perforated acute appendicitis compared to those with a non-perforated simple appendicitis(1.04±05 mg/dl vs 0.7±0.1 mg/dl) and this difference is highly significant (p<0.01). CONCLUSION: Assessment of preoperative total bilirubin is useful for the differential diagnosis of perforatedversus acute simple appendicitis and total bilirubin should be used as an independent parameter in the early diagnosisof appendix perforation Iran University of Medical Sciences 2013-08 /pmc/articles/PMC3917482/ /pubmed/24791119 Text en © 2013 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Vaziri, Mohammad
Pazouki, Abdolreza
Tamannaie, Zeinab
Maghsoudloo, Farshid
Pishgahroudsari, Mohadeseh
Chaichian, Shahla
Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis
title Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis
title_full Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis
title_fullStr Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis
title_full_unstemmed Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis
title_short Comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis
title_sort comparison of pre-operative bilirubin level in simple appendicitis and perforated appendicitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917482/
https://www.ncbi.nlm.nih.gov/pubmed/24791119
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