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Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
BACKGROUND: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917537/ https://www.ncbi.nlm.nih.gov/pubmed/24468306 http://dx.doi.org/10.1186/1869-5760-4-2 |
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author | Burkholder, Bryn M Leung, Theresa G Ostheimer, Trucian A Butler, Nicholas J Thorne, Jennifer E Dunn, James P |
author_facet | Burkholder, Bryn M Leung, Theresa G Ostheimer, Trucian A Butler, Nicholas J Thorne, Jennifer E Dunn, James P |
author_sort | Burkholder, Bryn M |
collection | PubMed |
description | BACKGROUND: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information about the pathophysiology of the disease. FINDINGS: We report a series of three consecutive patients seen at the Wilmer Eye Institute in 2012 and 2013 who presented with clinical and laboratory findings consistent with a diagnosis of unilateral ASPPC. Two of the three patients had HIV co-infection with good immune recovery. SD-OCT images from their initial (pre-treatment) presentation demonstrated thickening and hyperreflective nodularity of the choroid-retinal pigment epithelium (RPE) complex, with focal disruption of the overlying photoreceptor inner segment-outer segment junction in the areas corresponding to the retinal lesions seen on clinical examination. These changes improved with intravenous antibiotic treatment over a 3-month period of follow-up. CONCLUSIONS: SD-OCT imaging in ASPPC demonstrates reversible, focal thickening, and nodularity of the RPE with disruption of the overlying photoreceptor inner segment-outer segment junction. We believe that these SD-OCT images support the concept that ASPPC involves an inflammatory process at the level of the choroid-RPE with resultant structural and functional changes in the retinal photoreceptors. Further study with OCT imaging may be helpful in better understanding this disease. |
format | Online Article Text |
id | pubmed-3917537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-39175372014-02-20 Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis Burkholder, Bryn M Leung, Theresa G Ostheimer, Trucian A Butler, Nicholas J Thorne, Jennifer E Dunn, James P J Ophthalmic Inflamm Infect Brief Report BACKGROUND: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information about the pathophysiology of the disease. FINDINGS: We report a series of three consecutive patients seen at the Wilmer Eye Institute in 2012 and 2013 who presented with clinical and laboratory findings consistent with a diagnosis of unilateral ASPPC. Two of the three patients had HIV co-infection with good immune recovery. SD-OCT images from their initial (pre-treatment) presentation demonstrated thickening and hyperreflective nodularity of the choroid-retinal pigment epithelium (RPE) complex, with focal disruption of the overlying photoreceptor inner segment-outer segment junction in the areas corresponding to the retinal lesions seen on clinical examination. These changes improved with intravenous antibiotic treatment over a 3-month period of follow-up. CONCLUSIONS: SD-OCT imaging in ASPPC demonstrates reversible, focal thickening, and nodularity of the RPE with disruption of the overlying photoreceptor inner segment-outer segment junction. We believe that these SD-OCT images support the concept that ASPPC involves an inflammatory process at the level of the choroid-RPE with resultant structural and functional changes in the retinal photoreceptors. Further study with OCT imaging may be helpful in better understanding this disease. Springer 2014-01-27 /pmc/articles/PMC3917537/ /pubmed/24468306 http://dx.doi.org/10.1186/1869-5760-4-2 Text en Copyright © 2014 Burkholder et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Report Burkholder, Bryn M Leung, Theresa G Ostheimer, Trucian A Butler, Nicholas J Thorne, Jennifer E Dunn, James P Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis |
title | Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis |
title_full | Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis |
title_fullStr | Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis |
title_full_unstemmed | Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis |
title_short | Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis |
title_sort | spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917537/ https://www.ncbi.nlm.nih.gov/pubmed/24468306 http://dx.doi.org/10.1186/1869-5760-4-2 |
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