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Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis

BACKGROUND: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information...

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Autores principales: Burkholder, Bryn M, Leung, Theresa G, Ostheimer, Trucian A, Butler, Nicholas J, Thorne, Jennifer E, Dunn, James P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917537/
https://www.ncbi.nlm.nih.gov/pubmed/24468306
http://dx.doi.org/10.1186/1869-5760-4-2
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author Burkholder, Bryn M
Leung, Theresa G
Ostheimer, Trucian A
Butler, Nicholas J
Thorne, Jennifer E
Dunn, James P
author_facet Burkholder, Bryn M
Leung, Theresa G
Ostheimer, Trucian A
Butler, Nicholas J
Thorne, Jennifer E
Dunn, James P
author_sort Burkholder, Bryn M
collection PubMed
description BACKGROUND: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information about the pathophysiology of the disease. FINDINGS: We report a series of three consecutive patients seen at the Wilmer Eye Institute in 2012 and 2013 who presented with clinical and laboratory findings consistent with a diagnosis of unilateral ASPPC. Two of the three patients had HIV co-infection with good immune recovery. SD-OCT images from their initial (pre-treatment) presentation demonstrated thickening and hyperreflective nodularity of the choroid-retinal pigment epithelium (RPE) complex, with focal disruption of the overlying photoreceptor inner segment-outer segment junction in the areas corresponding to the retinal lesions seen on clinical examination. These changes improved with intravenous antibiotic treatment over a 3-month period of follow-up. CONCLUSIONS: SD-OCT imaging in ASPPC demonstrates reversible, focal thickening, and nodularity of the RPE with disruption of the overlying photoreceptor inner segment-outer segment junction. We believe that these SD-OCT images support the concept that ASPPC involves an inflammatory process at the level of the choroid-RPE with resultant structural and functional changes in the retinal photoreceptors. Further study with OCT imaging may be helpful in better understanding this disease.
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spelling pubmed-39175372014-02-20 Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis Burkholder, Bryn M Leung, Theresa G Ostheimer, Trucian A Butler, Nicholas J Thorne, Jennifer E Dunn, James P J Ophthalmic Inflamm Infect Brief Report BACKGROUND: We describe the spectral domain optical coherence tomography (SD-OCT) findings in three patients with acute syphilitic posterior placoid chorioretinitis (ASPPC). The SD-OCT images demonstrate the pathologic changes in ASPPC with a high level of anatomic detail and may provide information about the pathophysiology of the disease. FINDINGS: We report a series of three consecutive patients seen at the Wilmer Eye Institute in 2012 and 2013 who presented with clinical and laboratory findings consistent with a diagnosis of unilateral ASPPC. Two of the three patients had HIV co-infection with good immune recovery. SD-OCT images from their initial (pre-treatment) presentation demonstrated thickening and hyperreflective nodularity of the choroid-retinal pigment epithelium (RPE) complex, with focal disruption of the overlying photoreceptor inner segment-outer segment junction in the areas corresponding to the retinal lesions seen on clinical examination. These changes improved with intravenous antibiotic treatment over a 3-month period of follow-up. CONCLUSIONS: SD-OCT imaging in ASPPC demonstrates reversible, focal thickening, and nodularity of the RPE with disruption of the overlying photoreceptor inner segment-outer segment junction. We believe that these SD-OCT images support the concept that ASPPC involves an inflammatory process at the level of the choroid-RPE with resultant structural and functional changes in the retinal photoreceptors. Further study with OCT imaging may be helpful in better understanding this disease. Springer 2014-01-27 /pmc/articles/PMC3917537/ /pubmed/24468306 http://dx.doi.org/10.1186/1869-5760-4-2 Text en Copyright © 2014 Burkholder et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Burkholder, Bryn M
Leung, Theresa G
Ostheimer, Trucian A
Butler, Nicholas J
Thorne, Jennifer E
Dunn, James P
Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
title Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
title_full Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
title_fullStr Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
title_full_unstemmed Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
title_short Spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
title_sort spectral domain optical coherence tomography findings in acute syphilitic posterior placoid chorioretinitis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917537/
https://www.ncbi.nlm.nih.gov/pubmed/24468306
http://dx.doi.org/10.1186/1869-5760-4-2
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