Optimization of an AMBER Force Field for the Artificial Nucleic Acid, LNA, and Benchmarking with NMR of L(CAAU)

[Image: see text] Locked Nucleic Acids (LNAs) are RNA analogues with an O2′-C4′ methylene bridge which locks the sugar into a C3′-endo conformation. This enhances hybridization to DNA and RNA, making LNAs useful in microarrays and potential therapeutics. Here, the LNA, L(CAAU), provides a simplified...

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Detalles Bibliográficos
Autores principales: Condon, David E., Yildirim, Ilyas, Kennedy, Scott D., Mort, Brendan C., Kierzek, Ryszard, Turner, Douglas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917691/
https://www.ncbi.nlm.nih.gov/pubmed/24377321
http://dx.doi.org/10.1021/jp408909t

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917691/
https://www.ncbi.nlm.nih.gov/pubmed/24377321
http://dx.doi.org/10.1021/jp408909t

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