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Using multiple genetic variants as instrumental variables for modifiable risk factors

Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants typically explain a small proportion of the variability in risk factors; hence Mendelian randomisation analyses can requir...

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Detalles Bibliográficos
Autores principales:	Palmer, Tom M, Lawlor, Debbie A, Harbord, Roger M, Sheehan, Nuala A, Tobias, Jon H, Timpson, Nicholas J, Smith, George Davey, Sterne, Jonathan AC
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917707/ https://www.ncbi.nlm.nih.gov/pubmed/21216802 http://dx.doi.org/10.1177/0962280210394459

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