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NF-κB is a Critical Mediator of BRCA1 induced Chemoresistance

BRCA1 mediates resistance to apoptosis in response to DNA damaging agents, causing BRCA1 wild-type tumours to be significantly more resistant to DNA damage than their mutant counterparts. In this study we demonstrate that following treatment with the DNA damaging agents etoposide or camptothecin, BR...

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Detalles Bibliográficos
Autores principales:	Harte, Mary T, Gorski, Julia J, Savage, Kienan I, Purcell, James W, Barros, Eliana M, Burn, Philip M, McFarlane, Cheryl, Mullan, Paul B, Kennedy, Richard D, Perkins, Neil D, Harkin, D Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917825/ https://www.ncbi.nlm.nih.gov/pubmed/23435429 http://dx.doi.org/10.1038/onc.2013.10

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