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Abnormal White Matter Integrity in the Corpus Callosum among Smokers: Tract-Based Spatial Statistics

In the present study, we aimed to investigate the difference in white matter between smokers and nonsmokers. In addition, we examined relationships between white matter integrity and nicotine dependence parameters in smoking subjects. Nineteen male smokers were enrolled in this study. Eighteen age-m...

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Detalles Bibliográficos
Autores principales: Umene-Nakano, Wakako, Yoshimura, Reiji, Kakeda, Shingo, Watanabe, Keita, Hayashi, Kenji, Nishimura, Joji, Takahashi, Hidehiko, Moriya, Junji, Ide, Satoru, Ueda, Issei, Hori, Hikaru, Ikenouchi-Sugita, Atsuko, Katsuki, Asuka, Atake, Kiyokazu, Abe, Osamu, Korogi, Yukunori, Nakamura, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917830/
https://www.ncbi.nlm.nih.gov/pubmed/24516568
http://dx.doi.org/10.1371/journal.pone.0087890
Descripción
Sumario:In the present study, we aimed to investigate the difference in white matter between smokers and nonsmokers. In addition, we examined relationships between white matter integrity and nicotine dependence parameters in smoking subjects. Nineteen male smokers were enrolled in this study. Eighteen age-matched non-smokers with no current or past psychiatric history were included as controls. Diffusion tensor imaging scans were performed, and the analysis was conducted using a tract-based special statistics approach. Compared with nonsmokers, smokers exhibited a significant decrease in fractional anisotropy (FA) throughout the whole corpus callosum. There were no significant differences in radial diffusivity or axial diffusivity between the two groups. There was a significant negative correlation between FA in the whole corpus callosum and the amount of tobacco use (cigarettes/day; R = − 0.580, p = 0.023). These results suggest that the corpus callosum may be one of the key areas influenced by chronic smoking.