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High-Resolution Structure of the N-Terminal Endonuclease Domain of the Lassa Virus L Polymerase in Complex with Magnesium Ions

Lassa virus (LASV) causes deadly hemorrhagic fever disease for which there are no vaccines and limited treatments. LASV-encoded L polymerase is required for viral RNA replication and transcription. The functional domains of L–a large protein of 2218 amino acid residues–are largely undefined, except...

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Detalles Bibliográficos
Autores principales:	Wallat, Gregor D., Huang, Qinfeng, Wang, Wenjian, Dong, Haohao, Ly, Hinh, Liang, Yuying, Dong, Changjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917842/ https://www.ncbi.nlm.nih.gov/pubmed/24516554 http://dx.doi.org/10.1371/journal.pone.0087577

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