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DNA Double Strand Breaks as Predictor of Efficacy of the Alpha-Particle Emitter Ac-225 and the Electron Emitter Lu-177 for Somatostatin Receptor Targeted Radiotherapy

RATIONALE: Key biologic effects of the alpha-particle emitter Actinium-225 in comparison to the beta-particle emitter Lutetium-177 labeled somatostatin-analogue DOTATOC in vitro and in vivo were studied to evaluate the significance of γH2AX-foci formation. METHODS: To determine the relative biologic...

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Detalles Bibliográficos
Autores principales:	Graf, Franziska, Fahrer, Jörg, Maus, Stephan, Morgenstern, Alfred, Bruchertseifer, Frank, Venkatachalam, Senthil, Fottner, Christian, Weber, Matthias M., Huelsenbeck, Johannes, Schreckenberger, Mathias, Kaina, Bernd, Miederer, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917860/ https://www.ncbi.nlm.nih.gov/pubmed/24516620 http://dx.doi.org/10.1371/journal.pone.0088239

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