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Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma

BACKGROUND: The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL). METHODS: The medical records of three eyes from three patients with biopsy-proven PIOL...

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Autores principales: Egawa, Mariko, Mitamura, Yoshinori, Hayashi, Yuki, Naito, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917953/
https://www.ncbi.nlm.nih.gov/pubmed/24520190
http://dx.doi.org/10.2147/OPTH.S58114
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author Egawa, Mariko
Mitamura, Yoshinori
Hayashi, Yuki
Naito, Takeshi
author_facet Egawa, Mariko
Mitamura, Yoshinori
Hayashi, Yuki
Naito, Takeshi
author_sort Egawa, Mariko
collection PubMed
description BACKGROUND: The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL). METHODS: The medical records of three eyes from three patients with biopsy-proven PIOL and retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic findings were evaluated in the three eyes and FAF images in two eyes. RESULTS: The PIOL in the three patients was monocular. Vitreous opacities and retinal infiltrations were observed in the three eyes, and iritis was present in two eyes. The cytologic diagnosis was class V in two eyes and class III in one eye. The interleukin-10/interleukin-6 ratio was >1.0 in the vitreous and aqueous humor of the three eyes. The FAF images for two eyes showed abnormal granular hyperautofluorescence and hypoautofluorescence which were the reverse of the pattern in the fluorescein angiographic images. In all three eyes, SD-OCT showed hyper-reflective infiltrations at the level of the retinal pigment epithelium (RPE), a separation of the Bruch membrane from the RPE, damage to the RPE, disruption of the photoreceptor inner segment/outer segment junction, and multiple hyper-reflective signals in the inner retina. CONCLUSION: Because of the characteristic FAF and SD-OCT findings in these eyes with PIOL, we suggest that these noninvasive methods may be used for a rapid diagnosis of PIOL and also for understanding the pathology of PIOL.
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spelling pubmed-39179532014-02-11 Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma Egawa, Mariko Mitamura, Yoshinori Hayashi, Yuki Naito, Takeshi Clin Ophthalmol Case Series BACKGROUND: The purpose of this study was to evaluate the findings on spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in three eyes with primary intraocular lymphoma (PIOL). METHODS: The medical records of three eyes from three patients with biopsy-proven PIOL and retinal infiltrations were reviewed. The SD-OCT and fluorescein angiographic findings were evaluated in the three eyes and FAF images in two eyes. RESULTS: The PIOL in the three patients was monocular. Vitreous opacities and retinal infiltrations were observed in the three eyes, and iritis was present in two eyes. The cytologic diagnosis was class V in two eyes and class III in one eye. The interleukin-10/interleukin-6 ratio was >1.0 in the vitreous and aqueous humor of the three eyes. The FAF images for two eyes showed abnormal granular hyperautofluorescence and hypoautofluorescence which were the reverse of the pattern in the fluorescein angiographic images. In all three eyes, SD-OCT showed hyper-reflective infiltrations at the level of the retinal pigment epithelium (RPE), a separation of the Bruch membrane from the RPE, damage to the RPE, disruption of the photoreceptor inner segment/outer segment junction, and multiple hyper-reflective signals in the inner retina. CONCLUSION: Because of the characteristic FAF and SD-OCT findings in these eyes with PIOL, we suggest that these noninvasive methods may be used for a rapid diagnosis of PIOL and also for understanding the pathology of PIOL. Dove Medical Press 2014-01-31 /pmc/articles/PMC3917953/ /pubmed/24520190 http://dx.doi.org/10.2147/OPTH.S58114 Text en © 2014 Egawa et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Series
Egawa, Mariko
Mitamura, Yoshinori
Hayashi, Yuki
Naito, Takeshi
Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_full Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_fullStr Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_full_unstemmed Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_short Spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
title_sort spectral-domain optical coherence tomographic and fundus autofluorescence findings in eyes with primary intraocular lymphoma
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917953/
https://www.ncbi.nlm.nih.gov/pubmed/24520190
http://dx.doi.org/10.2147/OPTH.S58114
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