Cargando…
Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability
Changes in cell adhesion and polarity are closely associated with epithelial cell transformation and metastatic capacity. The tumor suppressor protein ASPP2 has been implicated in control of cell adhesion and polarity, through its effect on the PAR complex. Here we demonstrate that under hypoxic con...
Autores principales: | Kim, Hyungsoo, Claps, Guisepinna, Möller, Andreas, Bowtell, David, Lu, Xin, Ronai, Ze'ev A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917971/ https://www.ncbi.nlm.nih.gov/pubmed/23644657 http://dx.doi.org/10.1038/onc.2013.149 |
Ejemplares similares
-
Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2
por: Scortegagna, Marzia, et al.
Publicado: (2014) -
The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities
por: Qi, Jianfei, et al.
Publicado: (2010) -
Rewired Notch/p53 by Numb’ing Mdm2
por: Kim, Hyungsoo, et al.
Publicado: (2018) -
PRMT5 function and targeting in cancer
por: Kim, Hyungsoo, et al.
Publicado: (2020) -
Siah2 control of T-regulatory cells limits anti-tumor immunity
por: Scortegagna, Marzia, et al.
Publicado: (2020)