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The association between liver enzymes and risk of type 2 diabetes: the Namwon study

BACKGROUND: We examined the association between liver enzymes and development of type 2 diabetes in a general Korean population. METHODS: A total of 10,667 subjects (4,201 males and 6,466 females) aged 45 to 74 years participated in a baseline examination between 2004 and 2007. Among the subjects, 8...

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Detalles Bibliográficos
Autores principales: Ahn, Hye-Ran, Shin, Min-Ho, Nam, Hae-Sung, Park, Kyeong-Soo, Lee, Young-Hoon, Jeong, Seul-Ki, Choi, Jin-Su, Kweon, Sun-Seog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918101/
https://www.ncbi.nlm.nih.gov/pubmed/24502834
http://dx.doi.org/10.1186/1758-5996-6-14
Descripción
Sumario:BACKGROUND: We examined the association between liver enzymes and development of type 2 diabetes in a general Korean population. METHODS: A total of 10,667 subjects (4,201 males and 6,466 females) aged 45 to 74 years participated in a baseline examination between 2004 and 2007. Among the subjects, 8,157 (3,231 males and 4,926 females) underwent follow-up examination from 2007 to 2011, for a median follow-up period of 4.2 years. Type 2 diabetes was defined as intake of anti-diabetic agents, insulin treatment, fasting glucose concentration of more than 126 mg/dl, or hemoglobin A1c of more than 6.5% at re-examination. Associations of liver enzymes with incidence of type 2 diabetes were analyzed using logistic regression models. RESULTS: During the follow-up period, 548 subjects (235 males, 313 females) developed type 2 diabetes. After adjusting for comprehensive diabetes risk factor, the risk of type 2 diabetes was significantly higher in the highest alanine aminotransferase (ALT) quartile than in the lowest quartile (odds ratio (OR): 1.95, 95% confidence interval (CI): 1.18-3.21 in males; OR: 1.49, 95% CI: 1.03-2.16 in females). Similar results were observed for gamma-glutamyltransferase (GGT) quartiles, but in the fully adjusted analysis, the OR for the highest versus lowest quartiles was significant only for females (OR: 1.58, 95% CI: 0.95-2.63 in males; OR: 1.85, 95% CI: 1.23-2.79 in females). CONCLUSIONS: Our results suggest that serum ALT concentrations were independently associated with type 2 diabetes in both sexes, and that GGT was also independently associated but only in females.