Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: Involvement of the RB-microRNA axis

BACKGROUND: The HECT family ubiquitin ligase Smurf2 regulates cell polarity, migration, division, differentiation and death, by targeting diverse substrates that are critical for receptor signaling, cytoskeleton, chromatin remodeling and transcription. Recent studies suggest that Smurf2 functions as...

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Detalles Bibliográficos
Autores principales: Liu, Xianpeng, Gu, Xin, Sun, Limin, Flowers, Ashley B, Rademaker, Alfred W, Zhou, Yiran, Kiyokawa, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918234/
https://www.ncbi.nlm.nih.gov/pubmed/24485087
http://dx.doi.org/10.1186/1471-2407-14-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918234/
https://www.ncbi.nlm.nih.gov/pubmed/24485087
http://dx.doi.org/10.1186/1471-2407-14-57

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