Cargando…

Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: Involvement of the RB-microRNA axis

BACKGROUND: The HECT family ubiquitin ligase Smurf2 regulates cell polarity, migration, division, differentiation and death, by targeting diverse substrates that are critical for receptor signaling, cytoskeleton, chromatin remodeling and transcription. Recent studies suggest that Smurf2 functions as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xianpeng, Gu, Xin, Sun, Limin, Flowers, Ashley B, Rademaker, Alfred W, Zhou, Yiran, Kiyokawa, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918234/ https://www.ncbi.nlm.nih.gov/pubmed/24485087 http://dx.doi.org/10.1186/1471-2407-14-57

Ejemplares similares

Activity of Smurf2 Ubiquitin Ligase Is Regulated by the Wnt Pathway Protein Dishevelled
por: Bernatik, Ondrej, et al.
Publicado: (2020)

The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells
por: Liu, Xianpeng, et al.
Publicado: (2017)

The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint
por: Osmundson, Evan C., et al.
Publicado: (2008)

Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1
por: Zhang, Yuan, et al.
Publicado: (2016)

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase
por: Zhao, Shuai, et al.
Publicado: (2021)

E3 ubiquitin ligase Smurf2: a prognostic factor in microsatellite stable colorectal cancer
por: Klupp, Fee, et al.
Publicado: (2019)

Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1
por: Scott, Jordan L., et al.
Publicado: (2020)

Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs
por: Shepley-McTaggart, Ariel, et al.
Publicado: (2021)

Uncovering new insights into the role of the ubiquitin ligase Smurf1 on the regulation of innate immune signaling and resistance to infection
por: Souza-Costa, Luiz Pedro, et al.
Publicado: (2023)

Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer
por: Emanuelli, Andrea, et al.
Publicado: (2019)

Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
por: Liu, Xianpeng, et al.
Publicado: (2017)

Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma
por: Ke, Mang, et al.
Publicado: (2017)

Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
por: Osmundson, Evan C, et al.
Publicado: (2009)

Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner
por: David, Diana, et al.
Publicado: (2014)

Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression
por: David, Diana, et al.
Publicado: (2018)

The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
por: Koefoed, K., et al.
Publicado: (2018)

TRAF4 positively regulates the osteogenic differentiation of mesenchymal stem cells by acting as an E3 ubiquitin ligase to degrade Smurf2
por: Li, Jinteng, et al.
Publicado: (2019)

Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-β/Smads Signal Transduction
por: Zou, Junju, et al.
Publicado: (2022)

The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and Tissues
por: Shah, Pooja Anil, et al.
Publicado: (2022)

Retraction statement: Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma
Publicado: (2022)

Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation
por: Zhang, Weiwei, et al.
Publicado: (2017)

Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer
por: Wang, Yiyang, et al.
Publicado: (2017)

The E3 ubiquitin ligase Smurf2 regulates PARP1 stability to alleviate oxidative stress‐induced injury in human umbilical vein endothelial cells
por: Qian, Hao, et al.
Publicado: (2020)

Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation
por: Wei, Xiaofan, et al.
Publicado: (2017)

Smurf1 regulates ameloblast polarization by ubiquitination‐mediated degradation of RhoA
por: Niu, Haoman, et al.
Publicado: (2022)

Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression
por: Du, Lei, et al.
Publicado: (2020)

Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth
por: Feng, Xing, et al.
Publicado: (2019)

Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2
por: Song, Dongqiang, et al.
Publicado: (2022)

Bortezomib Rescues Ovariectomy-Induced Bone Loss via SMURF-Mediated Ubiquitination Pathway
por: Fang, Yuepeng, et al.
Publicado: (2021)

Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells
por: Kim, Donghee, et al.
Publicado: (2022)

Profiling and verifying the substrates of E3 ubiquitin ligase Rsp5 in yeast cells
por: Fang, Shuai, et al.
Publicado: (2023)

The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation
por: Moore, Finola E, et al.
Publicado: (2010)

Ubiquitin ligases and beyond
por: Dikic, Ivan, et al.
Publicado: (2012)

Adenovirus-mediated downregulation of the ubiquitin ligase RNF8 sensitizes bladder cancer to radiotherapy
por: Zhao, Mei-Jun, et al.
Publicado: (2016)

miR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression
por: Qi, Yuan, et al.
Publicado: (2022)

An anti-cancer Smurf
por: Zhao, Keji, et al.
Publicado: (2012)

The promotional effect of microRNA-103a-3p in cervical cancer cells by regulating the ubiquitin ligase FBXW7 function
por: Ren, Li, et al.
Publicado: (2022)

Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1
por: Ramkumar, Charusheila, et al.
Publicado: (2013)

Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis
por: Zhu, Kun, et al.
Publicado: (2018)

SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration
por: Chen, Xuri, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d35ioi2sej0jvtr5j3mj0n2g08