Immune and inflammatory pathways in NASH

Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen-associated molecular patterns and danger-associated molecular patterns are known to acti...

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Detalles Bibliográficos
Autores principales: Ganz, Michal, Szabo, Gyongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918407/
https://www.ncbi.nlm.nih.gov/pubmed/24587847
http://dx.doi.org/10.1007/s12072-013-9468-6
Descripción
Sumario:Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen-associated molecular patterns and danger-associated molecular patterns are known to activate a variety of pattern-recognition receptors that result in inflammation. The key features of the immune system and inflammatory pathways in the development of NAFLD are discussed in this review.

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