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Insulin resistance, steatosis and hepatitis C virus

Epidemiological studies have shown an increased occurrence of metabolic disorders such as insulin resistance (IR) and steatosis in patients with hepatitis C virus (HCV) infection. IR is believed to represent one of the central clinical features of the “metabolic syndrome” and the major pathogenetic...

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Detalles Bibliográficos
Autores principales: Mangia, Alessandra, Ripoli, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918408/
https://www.ncbi.nlm.nih.gov/pubmed/24587848
http://dx.doi.org/10.1007/s12072-013-9460-1
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author Mangia, Alessandra
Ripoli, Maria
author_facet Mangia, Alessandra
Ripoli, Maria
author_sort Mangia, Alessandra
collection PubMed
description Epidemiological studies have shown an increased occurrence of metabolic disorders such as insulin resistance (IR) and steatosis in patients with hepatitis C virus (HCV) infection. IR is believed to represent one of the central clinical features of the “metabolic syndrome” and the major pathogenetic factor for type 2 diabetes mellitus. In patients with chronic HCV hepatitis, IR may have several dangerous consequences such as accelerated progression of liver fibrosis, resistance to antiviral therapy and development of hepatocellular carcinoma. According to recent evidence, the global epidemic of metabolic disorders related to incorrect diets will lead physicians to deal with 1.2 billion patients with diabetes in the world in 2025. Given the high prevalence of HCV infection in several countries, metabolic manifestations will contribute to increasing morbidity and mortality in patients with HCV chronic infection in the near future. HCV treatment, shown able to decrease both the occurrence of HCV-related IR and diabetes, may reduce the risk of the associated morbidities.
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spelling pubmed-39184082014-02-28 Insulin resistance, steatosis and hepatitis C virus Mangia, Alessandra Ripoli, Maria Hepatol Int Review Article Epidemiological studies have shown an increased occurrence of metabolic disorders such as insulin resistance (IR) and steatosis in patients with hepatitis C virus (HCV) infection. IR is believed to represent one of the central clinical features of the “metabolic syndrome” and the major pathogenetic factor for type 2 diabetes mellitus. In patients with chronic HCV hepatitis, IR may have several dangerous consequences such as accelerated progression of liver fibrosis, resistance to antiviral therapy and development of hepatocellular carcinoma. According to recent evidence, the global epidemic of metabolic disorders related to incorrect diets will lead physicians to deal with 1.2 billion patients with diabetes in the world in 2025. Given the high prevalence of HCV infection in several countries, metabolic manifestations will contribute to increasing morbidity and mortality in patients with HCV chronic infection in the near future. HCV treatment, shown able to decrease both the occurrence of HCV-related IR and diabetes, may reduce the risk of the associated morbidities. Springer India 2013-08-27 /pmc/articles/PMC3918408/ /pubmed/24587848 http://dx.doi.org/10.1007/s12072-013-9460-1 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review Article
Mangia, Alessandra
Ripoli, Maria
Insulin resistance, steatosis and hepatitis C virus
title Insulin resistance, steatosis and hepatitis C virus
title_full Insulin resistance, steatosis and hepatitis C virus
title_fullStr Insulin resistance, steatosis and hepatitis C virus
title_full_unstemmed Insulin resistance, steatosis and hepatitis C virus
title_short Insulin resistance, steatosis and hepatitis C virus
title_sort insulin resistance, steatosis and hepatitis c virus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918408/
https://www.ncbi.nlm.nih.gov/pubmed/24587848
http://dx.doi.org/10.1007/s12072-013-9460-1
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