Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer’s disease (AD). However, how CCH causes cognitive impairment and contributes to Alzheimer’s pathology is poorly understood. Here we produced a mouse model of CCH by un...

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Detalles Bibliográficos
Autores principales: Zhao, Yang, Gu, Jin-hua, Dai, Chun-ling, Liu, Qun, Iqbal, Khalid, Liu, Fei, Gong, Cheng-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918671/
https://www.ncbi.nlm.nih.gov/pubmed/24575038
http://dx.doi.org/10.3389/fnagi.2014.00010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918671/
https://www.ncbi.nlm.nih.gov/pubmed/24575038
http://dx.doi.org/10.3389/fnagi.2014.00010

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