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Serum and Urinary NGAL in Septic Newborns

Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determi...

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Autores principales: Smertka, Mike, Wroblewska, Jolanta, Suchojad, Anna, Majcherczyk, Malgorzata, Jadamus-Niebroj, Danuta, Owsianka-Podlesny, Teresa, Brzozowska, Aniceta, Maruniak-Chudek, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918693/
https://www.ncbi.nlm.nih.gov/pubmed/24579085
http://dx.doi.org/10.1155/2014/717318
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author Smertka, Mike
Wroblewska, Jolanta
Suchojad, Anna
Majcherczyk, Malgorzata
Jadamus-Niebroj, Danuta
Owsianka-Podlesny, Teresa
Brzozowska, Aniceta
Maruniak-Chudek, Iwona
author_facet Smertka, Mike
Wroblewska, Jolanta
Suchojad, Anna
Majcherczyk, Malgorzata
Jadamus-Niebroj, Danuta
Owsianka-Podlesny, Teresa
Brzozowska, Aniceta
Maruniak-Chudek, Iwona
author_sort Smertka, Mike
collection PubMed
description Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determined serum and urine NGAL concentrations in 73 infants (51 with sepsis; 22 with severe sepsis) admitted to the Intensive Care Unit in the first month of life, for three consecutive days during the course of treatment for infection. 29 neonates without infection served as the control group. Septic patients, in particular, severe sepsis patients, had increased serum and urinary NGAL levels in the three subsequent days of observation. Five septic patients who developed AKI had elevated serum and urinary NGAL values to a similar extent as septic neonates without AKI. A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers, such as CRP and procalcitonin. Serum and urinary NGAL levels were also significantly associated with NTISS (neonatal therapeutic intervention scoring system) values. We conclude that increased serum and urinary NGAL values are not solely a marker of AKI, and more accurately reflect the severity of inflammatory status.
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spelling pubmed-39186932014-02-26 Serum and Urinary NGAL in Septic Newborns Smertka, Mike Wroblewska, Jolanta Suchojad, Anna Majcherczyk, Malgorzata Jadamus-Niebroj, Danuta Owsianka-Podlesny, Teresa Brzozowska, Aniceta Maruniak-Chudek, Iwona Biomed Res Int Research Article Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determined serum and urine NGAL concentrations in 73 infants (51 with sepsis; 22 with severe sepsis) admitted to the Intensive Care Unit in the first month of life, for three consecutive days during the course of treatment for infection. 29 neonates without infection served as the control group. Septic patients, in particular, severe sepsis patients, had increased serum and urinary NGAL levels in the three subsequent days of observation. Five septic patients who developed AKI had elevated serum and urinary NGAL values to a similar extent as septic neonates without AKI. A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers, such as CRP and procalcitonin. Serum and urinary NGAL levels were also significantly associated with NTISS (neonatal therapeutic intervention scoring system) values. We conclude that increased serum and urinary NGAL values are not solely a marker of AKI, and more accurately reflect the severity of inflammatory status. Hindawi Publishing Corporation 2014 2014-01-21 /pmc/articles/PMC3918693/ /pubmed/24579085 http://dx.doi.org/10.1155/2014/717318 Text en Copyright © 2014 Mike Smertka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Smertka, Mike
Wroblewska, Jolanta
Suchojad, Anna
Majcherczyk, Malgorzata
Jadamus-Niebroj, Danuta
Owsianka-Podlesny, Teresa
Brzozowska, Aniceta
Maruniak-Chudek, Iwona
Serum and Urinary NGAL in Septic Newborns
title Serum and Urinary NGAL in Septic Newborns
title_full Serum and Urinary NGAL in Septic Newborns
title_fullStr Serum and Urinary NGAL in Septic Newborns
title_full_unstemmed Serum and Urinary NGAL in Septic Newborns
title_short Serum and Urinary NGAL in Septic Newborns
title_sort serum and urinary ngal in septic newborns
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918693/
https://www.ncbi.nlm.nih.gov/pubmed/24579085
http://dx.doi.org/10.1155/2014/717318
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