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Serum and Urinary NGAL in Septic Newborns
Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918693/ https://www.ncbi.nlm.nih.gov/pubmed/24579085 http://dx.doi.org/10.1155/2014/717318 |
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author | Smertka, Mike Wroblewska, Jolanta Suchojad, Anna Majcherczyk, Malgorzata Jadamus-Niebroj, Danuta Owsianka-Podlesny, Teresa Brzozowska, Aniceta Maruniak-Chudek, Iwona |
author_facet | Smertka, Mike Wroblewska, Jolanta Suchojad, Anna Majcherczyk, Malgorzata Jadamus-Niebroj, Danuta Owsianka-Podlesny, Teresa Brzozowska, Aniceta Maruniak-Chudek, Iwona |
author_sort | Smertka, Mike |
collection | PubMed |
description | Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determined serum and urine NGAL concentrations in 73 infants (51 with sepsis; 22 with severe sepsis) admitted to the Intensive Care Unit in the first month of life, for three consecutive days during the course of treatment for infection. 29 neonates without infection served as the control group. Septic patients, in particular, severe sepsis patients, had increased serum and urinary NGAL levels in the three subsequent days of observation. Five septic patients who developed AKI had elevated serum and urinary NGAL values to a similar extent as septic neonates without AKI. A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers, such as CRP and procalcitonin. Serum and urinary NGAL levels were also significantly associated with NTISS (neonatal therapeutic intervention scoring system) values. We conclude that increased serum and urinary NGAL values are not solely a marker of AKI, and more accurately reflect the severity of inflammatory status. |
format | Online Article Text |
id | pubmed-3918693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39186932014-02-26 Serum and Urinary NGAL in Septic Newborns Smertka, Mike Wroblewska, Jolanta Suchojad, Anna Majcherczyk, Malgorzata Jadamus-Niebroj, Danuta Owsianka-Podlesny, Teresa Brzozowska, Aniceta Maruniak-Chudek, Iwona Biomed Res Int Research Article Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determined serum and urine NGAL concentrations in 73 infants (51 with sepsis; 22 with severe sepsis) admitted to the Intensive Care Unit in the first month of life, for three consecutive days during the course of treatment for infection. 29 neonates without infection served as the control group. Septic patients, in particular, severe sepsis patients, had increased serum and urinary NGAL levels in the three subsequent days of observation. Five septic patients who developed AKI had elevated serum and urinary NGAL values to a similar extent as septic neonates without AKI. A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers, such as CRP and procalcitonin. Serum and urinary NGAL levels were also significantly associated with NTISS (neonatal therapeutic intervention scoring system) values. We conclude that increased serum and urinary NGAL values are not solely a marker of AKI, and more accurately reflect the severity of inflammatory status. Hindawi Publishing Corporation 2014 2014-01-21 /pmc/articles/PMC3918693/ /pubmed/24579085 http://dx.doi.org/10.1155/2014/717318 Text en Copyright © 2014 Mike Smertka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Smertka, Mike Wroblewska, Jolanta Suchojad, Anna Majcherczyk, Malgorzata Jadamus-Niebroj, Danuta Owsianka-Podlesny, Teresa Brzozowska, Aniceta Maruniak-Chudek, Iwona Serum and Urinary NGAL in Septic Newborns |
title | Serum and Urinary NGAL in Septic Newborns |
title_full | Serum and Urinary NGAL in Septic Newborns |
title_fullStr | Serum and Urinary NGAL in Septic Newborns |
title_full_unstemmed | Serum and Urinary NGAL in Septic Newborns |
title_short | Serum and Urinary NGAL in Septic Newborns |
title_sort | serum and urinary ngal in septic newborns |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918693/ https://www.ncbi.nlm.nih.gov/pubmed/24579085 http://dx.doi.org/10.1155/2014/717318 |
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