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Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?

To explore whether steroid therapy should be needed for autoimmune pancreatitis patients after operation, eight AIP patients receiving operation were enrolled in this study from January 2007 to July 2013. All patients underwent liver function, CA19-9, and contrast-enhanced CT and/or MRI. Tests of Ig...

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Autores principales: Wu, Wenchuan, Yao, Xiuzhong, Lin, Chao, Jin, Dayong, Wang, Dansong, Lou, Wenhui, Qin, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918699/
https://www.ncbi.nlm.nih.gov/pubmed/24578705
http://dx.doi.org/10.1155/2014/253471
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author Wu, Wenchuan
Yao, Xiuzhong
Lin, Chao
Jin, Dayong
Wang, Dansong
Lou, Wenhui
Qin, Xinyu
author_facet Wu, Wenchuan
Yao, Xiuzhong
Lin, Chao
Jin, Dayong
Wang, Dansong
Lou, Wenhui
Qin, Xinyu
author_sort Wu, Wenchuan
collection PubMed
description To explore whether steroid therapy should be needed for autoimmune pancreatitis patients after operation, eight AIP patients receiving operation were enrolled in this study from January 2007 to July 2013. All patients underwent liver function, CA19-9, and contrast-enhanced CT and/or MRI. Tests of IgG and IgG4 were performed in some patients. Tests of serum TB/DB, γ-GT, and γ-globulin were undergone during the perioperative period. Six cases receiving resection were pathologically confirmed as AIP patients and two were confirmed by intraoperative biopsy. For seven patients, TB/DB level was transiently elevated 1 day or 4 days after operation but dropped below preoperative levels or to normal levels 7 days after operation, and serum γ-GT level presented a downward trend. Serum γ-globulin level exhibited a downward trend among six AIP patients after resection, while an upward trend was found in another two AIP patients receiving internal drainage. Steroid therapy was not given to all six AIP patients until two of them showed new lines of evidence of residual or extrapancreatic AIP lesion after operation, while another two cases without resection received steroid medication. Steroid therapy might not be recommended unless there are new lines of evidence of residual extrapancreatic AIP lesions after resection.
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spelling pubmed-39186992014-02-26 Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy? Wu, Wenchuan Yao, Xiuzhong Lin, Chao Jin, Dayong Wang, Dansong Lou, Wenhui Qin, Xinyu Gastroenterol Res Pract Clinical Study To explore whether steroid therapy should be needed for autoimmune pancreatitis patients after operation, eight AIP patients receiving operation were enrolled in this study from January 2007 to July 2013. All patients underwent liver function, CA19-9, and contrast-enhanced CT and/or MRI. Tests of IgG and IgG4 were performed in some patients. Tests of serum TB/DB, γ-GT, and γ-globulin were undergone during the perioperative period. Six cases receiving resection were pathologically confirmed as AIP patients and two were confirmed by intraoperative biopsy. For seven patients, TB/DB level was transiently elevated 1 day or 4 days after operation but dropped below preoperative levels or to normal levels 7 days after operation, and serum γ-GT level presented a downward trend. Serum γ-globulin level exhibited a downward trend among six AIP patients after resection, while an upward trend was found in another two AIP patients receiving internal drainage. Steroid therapy was not given to all six AIP patients until two of them showed new lines of evidence of residual or extrapancreatic AIP lesion after operation, while another two cases without resection received steroid medication. Steroid therapy might not be recommended unless there are new lines of evidence of residual extrapancreatic AIP lesions after resection. Hindawi Publishing Corporation 2014 2014-01-22 /pmc/articles/PMC3918699/ /pubmed/24578705 http://dx.doi.org/10.1155/2014/253471 Text en Copyright © 2014 Wenchuan Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Wu, Wenchuan
Yao, Xiuzhong
Lin, Chao
Jin, Dayong
Wang, Dansong
Lou, Wenhui
Qin, Xinyu
Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
title Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
title_full Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
title_fullStr Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
title_full_unstemmed Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
title_short Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
title_sort should steroid therapy be necessarily needed for autoimmune pancreatitis patients with lesion resected due to misdiagnosed or suspected malignancy?
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918699/
https://www.ncbi.nlm.nih.gov/pubmed/24578705
http://dx.doi.org/10.1155/2014/253471
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