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Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits
Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sono...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918727/ https://www.ncbi.nlm.nih.gov/pubmed/24578637 http://dx.doi.org/10.1155/2014/504248 |
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author | Kasapas, Konstantinos Diamantopoulou, Angela Pentilas, Nicolaos Papalois, Apostolos Douzinas, Emmanuel Kouraklis, Gregorios Slama, Michel Terkawi, Abdullah Sulieman Blaivas, Michael Sargsyan, Ashot Ernest Karakitsos, Dimitrios |
author_facet | Kasapas, Konstantinos Diamantopoulou, Angela Pentilas, Nicolaos Papalois, Apostolos Douzinas, Emmanuel Kouraklis, Gregorios Slama, Michel Terkawi, Abdullah Sulieman Blaivas, Michael Sargsyan, Ashot Ernest Karakitsos, Dimitrios |
author_sort | Kasapas, Konstantinos |
collection | PubMed |
description | Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sonographic pupillary light reflex (PLR) test with invasive intracranial pressure (ICP) measurements. Material and Methods. Twenty rabbits participated in the study. An intraparenchymal ICP catheter and a 5F Swan-Ganz catheter (SG) for the hematoma reproduction were used. We successively introduced 0.1 mL increments of autologous blood into the SG until the Cushing reaction occurred. Synchronous ICP and ultrasound measurements were performed accordingly. Results. A constant increase of PI and ONSD and a decrease of V values were observed with increased ICP values. The relationship between the ultrasound variables and ICP was exponential; thus curved prediction equations of ICP were used. PI, ONSD, and V were significantly correlated with ICP (r (2) = 0.84 ± 0.076, r (2) = 0.62 ± 0.119, and r (2) = 0.78 ± 0.09, resp. (all P < 0.001)). Conclusion. Although statistically significant prediction models of ICP were derived from ultrasound indices, the exponential relationship between the parameters underpins that results should be interpreted with caution and in the current experimental context. |
format | Online Article Text |
id | pubmed-3918727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39187272014-02-26 Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits Kasapas, Konstantinos Diamantopoulou, Angela Pentilas, Nicolaos Papalois, Apostolos Douzinas, Emmanuel Kouraklis, Gregorios Slama, Michel Terkawi, Abdullah Sulieman Blaivas, Michael Sargsyan, Ashot Ernest Karakitsos, Dimitrios ScientificWorldJournal Research Article Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sonographic pupillary light reflex (PLR) test with invasive intracranial pressure (ICP) measurements. Material and Methods. Twenty rabbits participated in the study. An intraparenchymal ICP catheter and a 5F Swan-Ganz catheter (SG) for the hematoma reproduction were used. We successively introduced 0.1 mL increments of autologous blood into the SG until the Cushing reaction occurred. Synchronous ICP and ultrasound measurements were performed accordingly. Results. A constant increase of PI and ONSD and a decrease of V values were observed with increased ICP values. The relationship between the ultrasound variables and ICP was exponential; thus curved prediction equations of ICP were used. PI, ONSD, and V were significantly correlated with ICP (r (2) = 0.84 ± 0.076, r (2) = 0.62 ± 0.119, and r (2) = 0.78 ± 0.09, resp. (all P < 0.001)). Conclusion. Although statistically significant prediction models of ICP were derived from ultrasound indices, the exponential relationship between the parameters underpins that results should be interpreted with caution and in the current experimental context. Hindawi Publishing Corporation 2014-01-21 /pmc/articles/PMC3918727/ /pubmed/24578637 http://dx.doi.org/10.1155/2014/504248 Text en Copyright © 2014 Konstantinos Kasapas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kasapas, Konstantinos Diamantopoulou, Angela Pentilas, Nicolaos Papalois, Apostolos Douzinas, Emmanuel Kouraklis, Gregorios Slama, Michel Terkawi, Abdullah Sulieman Blaivas, Michael Sargsyan, Ashot Ernest Karakitsos, Dimitrios Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
title | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
title_full | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
title_fullStr | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
title_full_unstemmed | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
title_short | Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits |
title_sort | invasive and ultrasound based monitoring of the intracranial pressure in an experimental model of epidural hematoma progressing towards brain tamponade on rabbits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918727/ https://www.ncbi.nlm.nih.gov/pubmed/24578637 http://dx.doi.org/10.1155/2014/504248 |
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