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Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B
Humoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg ne...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918850/ https://www.ncbi.nlm.nih.gov/pubmed/24579055 http://dx.doi.org/10.1155/2014/896864 |
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author | Mohamadkhani, Ashraf Naderi, Elnaz Sotoudeh, Masoud Katoonizadeh, Aezam Montazeri, Ghodratollah Poustchi, Hossein |
author_facet | Mohamadkhani, Ashraf Naderi, Elnaz Sotoudeh, Masoud Katoonizadeh, Aezam Montazeri, Ghodratollah Poustchi, Hossein |
author_sort | Mohamadkhani, Ashraf |
collection | PubMed |
description | Humoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry. The patients' clinical data at the time of liver biopsy were acquired from their medical records. There was a significant association between log HBV DNA and both ALT (r = 0.36, P = 0.006) and histologic activity index (HAI) total score (r = 0.3, P = 0.02), respectively. The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (r = 0.32, P = 0.01) and stage of fibrosis (r = 0.31, P = 0.02). The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury. The present data also support that the liver is potentially one of the secondary lymphoid organs. |
format | Online Article Text |
id | pubmed-3918850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39188502014-02-26 Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B Mohamadkhani, Ashraf Naderi, Elnaz Sotoudeh, Masoud Katoonizadeh, Aezam Montazeri, Ghodratollah Poustchi, Hossein Int J Inflam Research Article Humoral immunity constitutes major defense mechanism against viral infections. However, the association of hepatic injury and B-cells population in chronic hepatitis B virus (HBV) carriers has not been studied well. In this study, fifty seven hepatitis B surface antigen (HBsAg) positive and HBeAg negative patients were studied to determine the expression of CD20, a cell surface marker expressed on B-cells, in liver biopsy sections using immunohistochemistry. The patients' clinical data at the time of liver biopsy were acquired from their medical records. There was a significant association between log HBV DNA and both ALT (r = 0.36, P = 0.006) and histologic activity index (HAI) total score (r = 0.3, P = 0.02), respectively. The CD20 was expressed in all 57 liver biopsy samples with a submembranous and membranous staining pattern and its expression was significantly associated with HAI total score (r = 0.32, P = 0.01) and stage of fibrosis (r = 0.31, P = 0.02). The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury. The present data also support that the liver is potentially one of the secondary lymphoid organs. Hindawi Publishing Corporation 2014 2014-01-21 /pmc/articles/PMC3918850/ /pubmed/24579055 http://dx.doi.org/10.1155/2014/896864 Text en Copyright © 2014 Ashraf Mohamadkhani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mohamadkhani, Ashraf Naderi, Elnaz Sotoudeh, Masoud Katoonizadeh, Aezam Montazeri, Ghodratollah Poustchi, Hossein Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
title | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
title_full | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
title_fullStr | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
title_full_unstemmed | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
title_short | Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B |
title_sort | clinical feature of intrahepatic b-lymphocytes in chronic hepatitis b |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918850/ https://www.ncbi.nlm.nih.gov/pubmed/24579055 http://dx.doi.org/10.1155/2014/896864 |
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