Cargando…

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

Recent evidence suggests that inhibition of bromodomain and extra-terminal (BET) epigenetic readers may have clinical utility against acute myeloid leukemia (AML). Here we validate this hypothesis, demonstrating the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes driven by di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dawson, M A, Gudgin, E J, Horton, S J, Giotopoulos, G, Meduri, E, Robson, S, Cannizzaro, E, Osaki, H, Wiese, M, Putwain, S, Fong, C Y, Grove, C, Craig, J, Dittmann, A, Lugo, D, Jeffrey, P, Drewes, G, Lee, K, Bullinger, L, Prinjha, R K, Kouzarides, T, Vassiliou, G S, Huntly, B J P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918873/ https://www.ncbi.nlm.nih.gov/pubmed/24220271 http://dx.doi.org/10.1038/leu.2013.338

Ejemplares similares

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression
por: Giotopoulos, George, et al.
Publicado: (2015)

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
por: McDuff, Fiona Kate Elizabeth, et al.
Publicado: (2011)

Acute myeloid leukemia: leukemia stem cells write a prognostic signature
por: Gudgin, Emma J, et al.
Publicado: (2011)

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity
por: Khoueiry, P., et al.
Publicado: (2019)

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
por: Tzelepis, Konstantinos, et al.
Publicado: (2018)

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/−) leukemia
por: van der Weyden, Louise, et al.
Publicado: (2015)

Oocyte Meiotic Competence in the Domestic Cat Model: Novel Roles for Nuclear Proteins BRD2 and NPM1
por: Chavez, Daniela R., et al.
Publicado: (2021)

S130: NPM1 MUTATED AML: IMPACT OF CO-MUTATIONAL PATTERNS - RESULTS OF THE EUROPEAN HARMONY ALLIANCE
por: Hernández-Sánchez, A., et al.
Publicado: (2022)

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML
por: Basheer, Faisal, et al.
Publicado: (2019)

Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture
por: Conte, N, et al.
Publicado: (2013)

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia
por: Hirsch, Susanne, et al.
Publicado: (2017)

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
por: Cocciardi, Sibylle, et al.
Publicado: (2019)

The RNA editing landscape in acute myeloid leukemia reveals associations with disease mutations and clinical outcome
por: Meduri, Eshwar, et al.
Publicado: (2022)

Mutational synergy during leukemia induction remodels chromatin accessibility, modification and 3-Dimensional DNA topology to alter gene expression
por: Yun, Haiyang, et al.
Publicado: (2021)

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
por: Roberts, Thomas C., et al.
Publicado: (2017)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell
por: Deeney, Jude T., et al.
Publicado: (2016)

Relapse of NPM1-Mutated AML with Extramedullary Manifestation 17 Years after Allogeneic Hematopoietic Stem Cell Transplantation
por: Braune, Jan, et al.
Publicado: (2022)

Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro
por: Caputo, Valentina S., et al.
Publicado: (2020)

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling
por: Okuwaki, Mitsuru, et al.
Publicado: (2012)

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias
por: Calero-Nieto, F J, et al.
Publicado: (2013)

Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice
por: Muranyi, Andrew, et al.
Publicado: (2022)

Inhibition of Rac controls NPM–ALK-dependent lymphoma development and dissemination
por: Colomba, A, et al.
Publicado: (2011)

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
por: Basilico, Silvia, et al.
Publicado: (2020)

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes
por: Darracq, Anaïs, et al.
Publicado: (2019)

NPM1 gene mutations can be confidently identified in blood DNA months before de novo AML onset
por: Quiros, Pedro M., et al.
Publicado: (2022)

Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
por: Fiskus, Warren, et al.
Publicado: (2022)

Identification of the BRD1 interaction network and its impact on mental disorder risk
por: Fryland, Tue, et al.
Publicado: (2016)

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes
por: Hügle, Martin, et al.
Publicado: (2016)

DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4
por: Cannizzaro, Ester, et al.
Publicado: (2018)

Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1
por: Mill, Christopher P., et al.
Publicado: (2023)

Normalization of NPM1 mutant transcript to the wild‐type transcript
por: Jennings, Lawrence J.
Publicado: (2022)

Clinical impact of NPM1-mutant molecular persistence after chemotherapy for acute myeloid leukemia
por: Tiong, Ing S., et al.
Publicado: (2021)

Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML
por: Diaz de la Guardia, Rafael, et al.
Publicado: (2020)

TPL2-NPM-p53 pathway monitors nucleolar stress
por: Eliopoulos, Aristides G., et al.
Publicado: (2015)

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development
por: Barrett, Neil A., et al.
Publicado: (2016)

NPM-ALK-reactive T-cell responses in children and adolescents with NPM-ALK positive anaplastic large cell lymphoma
por: Singh, Vijay Kumar, et al.
Publicado: (2019)

Bromodomain-containing subunits BRD1, BRD2, and BRD13 are required for proper functioning of SWI/SNF complexes in Arabidopsis
por: Jarończyk, Kamila, et al.
Publicado: (2021)

BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane
por: Alsarraj, Jude, et al.
Publicado: (2013)

Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay
por: McGlynn, A P, et al.
Publicado: (2003)

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
por: Chen, Yingyu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ko0h60l0ia778926fhauqmhgdn