Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA

The human immunodeficiency virus type 1 (HIV-1) Vpr protein binds to the cellular uracil–DNA glycosylase UNG2 and induces its degradation through the assembly with the DDB1-CUL4 ubiquitin ligase complex. This interaction counteracts the antiviral activity exerted by UNG2 on HIV-1 gene transcription,...

Descripción completa

Detalles Bibliográficos
Autores principales: Eldin, Patrick, Chazal, Nathalie, Fenard, David, Bernard, Eric, Guichou, Jean-François, Briant, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919559/
https://www.ncbi.nlm.nih.gov/pubmed/24178031
http://dx.doi.org/10.1093/nar/gkt974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919559/
https://www.ncbi.nlm.nih.gov/pubmed/24178031
http://dx.doi.org/10.1093/nar/gkt974

Ejemplares similares