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Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA

The human immunodeficiency virus type 1 (HIV-1) Vpr protein binds to the cellular uracil–DNA glycosylase UNG2 and induces its degradation through the assembly with the DDB1-CUL4 ubiquitin ligase complex. This interaction counteracts the antiviral activity exerted by UNG2 on HIV-1 gene transcription,...

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Detalles Bibliográficos
Autores principales:	Eldin, Patrick, Chazal, Nathalie, Fenard, David, Bernard, Eric, Guichou, Jean-François, Briant, Laurence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919559/ https://www.ncbi.nlm.nih.gov/pubmed/24178031 http://dx.doi.org/10.1093/nar/gkt974

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