Cargando…

Co-transcriptional production of RNA–DNA hybrids for simultaneous release of multiple split functionalities

Control over the simultaneous delivery of different functionalities and their synchronized intracellular activation can greatly benefit the fields of RNA and DNA biomedical nanotechnologies and allow for the production of nanoparticles and various switching devices with controllable functions. We pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Afonin, Kirill A., Desai, Ravi, Viard, Mathias, Kireeva, Maria L., Bindewald, Eckart, Case, Christopher L., Maciag, Anna E., Kasprzak, Wojciech K., Kim, Taejin, Sappe, Alison, Stepler, Marissa, KewalRamani, Vineet N., Kashlev, Mikhail, Blumenthal, Robert, Shapiro, Bruce A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919563/ https://www.ncbi.nlm.nih.gov/pubmed/24194608 http://dx.doi.org/10.1093/nar/gkt1001

Ejemplares similares

In Silico Design and Enzymatic Synthesis of Functional RNA Nanoparticles
por: Afonin, Kirill A., et al.
Publicado: (2014)

Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles
por: Afonin, Kirill A., et al.
Publicado: (2014)

Functionally-interdependent shape-switching nanoparticles with controllable properties
por: Halman, Justin R., et al.
Publicado: (2017)

Triggerable RNA nanodevices
por: Halman, Justin, et al.
Publicado: (2017)

Activation of different split functionalities upon re-association of RNA-DNA hybrids
por: Afonin, Kirill A., et al.
Publicado: (2013)

RNA–Protein Interactions Prevent Long RNA Duplex Formation: Implications for the Design of RNA-Based Therapeutics
por: Bindewald, Eckart, et al.
Publicado: (2018)

Structural polymorphism of the HIV-1 leader region explored by computational methods
por: Kasprzak, Wojciech, et al.
Publicado: (2005)

A Suite of Therapeutically-Inspired Nucleic Acid Logic Systems for Conditional Generation of Single-Stranded and Double-Stranded Oligonucleotides
por: Zakrevsky, Paul, et al.
Publicado: (2019)

In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery
por: Kim, Taejin, et al.
Publicado: (2013)

Triggering RNAi with multifunctional RNA nanoparticles and their delivery
por: Dao, Bich Ngoc, et al.
Publicado: (2015)

Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes
por: Unutmaz, Derya, et al.
Publicado: (1999)

In vitro Assembly of Cubic RNA-Based Scaffolds Designed in silico
por: Afonin, Kirill A, et al.
Publicado: (2010)

Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
por: Selyutina, Anastasia, et al.
Publicado: (2020)

The immunorecognition, subcellular compartmentalization, and physicochemical properties of nucleic acid nanoparticles can be controlled by composition modification
por: Johnson, Morgan Brittany, et al.
Publicado: (2020)

Directed evolution of recombinase specificity by split gene reassembly
por: Gersbach, Charles A., et al.
Publicado: (2010)

RNAJunction: a database of RNA junctions and kissing loops for three-dimensional structural analysis and nanodesign
por: Bindewald, Eckart, et al.
Publicado: (2008)

A split intein T7 RNA polymerase for transcriptional AND-logic
por: Schaerli, Yolanda, et al.
Publicado: (2014)

Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain
por: Kim, Taejin, et al.
Publicado: (2020)

Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission
por: Wu, Li, et al.
Publicado: (2004)

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection
por: Luchsinger, Charlotte, et al.
Publicado: (2023)

Efficient target cleavage by Type V Cas12a effectors programmed with split CRISPR RNA
por: Shebanova, Regina, et al.
Publicado: (2021)

Computational detection of abundant long-range nucleotide covariation in Drosophila genomes
por: Bindewald, Eckart, et al.
Publicado: (2013)

Sequence-independent RNA sensing and DNA targeting by a split domain CRISPR–Cas12a gRNA switch
por: Collins, Scott P, et al.
Publicado: (2021)

Multiplexed activation in mammalian cells using a split-intein CRISPR/Cas12a based synthetic transcription factor
por: Bryson, James W, et al.
Publicado: (2021)

Perturbation of the P-Body Component Mov10 Inhibits HIV-1 Infectivity
por: Furtak, Vyacheslav, et al.
Publicado: (2010)

CyloFold: secondary structure prediction including pseudoknots
por: Bindewald, Eckart, et al.
Publicado: (2010)

Predicting RNA SHAPE scores with deep learning
por: Bliss, Noah, et al.
Publicado: (2020)

RNA Toehold Interactions Initiate Conditional Gene Silencing
por: Zakrevsky, Paul, et al.
Publicado: (2016)

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats
por: Winans, Shelby, et al.
Publicado: (2022)

CorreLogo: an online server for 3D sequence logos of RNA and DNA alignments
por: Bindewald, Eckart, et al.
Publicado: (2006)

Multifunctional RNA Nanoparticles
por: Afonin, Kirill A., et al.
Publicado: (2014)

Oligonucleotide-mediated tRNA sequestration enables one-pot sense codon reassignment in vitro
por: Cui, Zhenling, et al.
Publicado: (2018)

Tandem repeat coupled with endonuclease cleavage (TREC): a seamless modification tool for genome engineering in yeast
por: Noskov, Vladimir N., et al.
Publicado: (2010)

Modular control of multiple pathways using engineered orthogonal T7 polymerases
por: Temme, Karsten, et al.
Publicado: (2012)

Synthetic biology: biology by design
por: Roberts, M. A. J., et al.
Publicado: (2013)

Tuning the dials of Synthetic Biology
por: Arpino, James A. J., et al.
Publicado: (2013)

A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile
por: Donald, Robert G. K., et al.
Publicado: (2013)

Computational protein design with backbone plasticity
por: MacDonald, James T., et al.
Publicado: (2016)

Evolution of DELLA function and signaling in land plants
por: Phokas, Alexandros, et al.
Publicado: (2021)

Recent advances in genetic tools for engineering probiotic lactic acid bacteria
por: Mugwanda, Kanganwiro, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tsseoioc3t77nfe2ckg1rsm8hv