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Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates

Flap endonuclease 1 (Fen1) is a highly conserved structure-specific nuclease that catalyses a specific incision to remove 5′ flaps in double-stranded DNA substrates. Fen1 plays an essential role in key cellular processes, such as DNA replication and repair, and mutations that compromise Fen1 express...

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Detalles Bibliográficos
Autores principales:	Craggs, Timothy D., Hutton, Richard D., Brenlla, Alfonso, White, Malcolm F., Penedo, J. Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919604/ https://www.ncbi.nlm.nih.gov/pubmed/24234453 http://dx.doi.org/10.1093/nar/gkt1116

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