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A cyclobutane thymine–N(4)-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis

Exposure of DNA to ultraviolet light produces harmful crosslinks between adjacent pyrimidine bases, to form cyclobutane pyrimidine dimers (CPDs) and pyrimidine(6–4)pyrimidone photoproducts. The CPD is frequently formed, and its repair mechanisms have been exclusively studied by using a CPD formed at...

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Detalles Bibliográficos
Autores principales:	Yamamoto, Junpei, Oyama, Tomoko, Kunishi, Tomohiro, Masutani, Chikahide, Hanaoka, Fumio, Iwai, Shigenori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919605/ https://www.ncbi.nlm.nih.gov/pubmed/24185703 http://dx.doi.org/10.1093/nar/gkt1039

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