Cargando…
A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya
BACKGROUND: Soil-transmitted helminths and schistosomiasis are mostly prevalent in developing countries due to poor sanitation and lack of adequate clean water. School-age children tend to be the target of chemotherapy-based control programmes because they carry the heaviest worm and egg burdens. Th...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919734/ https://www.ncbi.nlm.nih.gov/pubmed/24520365 http://dx.doi.org/10.1371/journal.pone.0088315 |
_version_ | 1782303070664785920 |
---|---|
author | Njenga, Sammy M. Ng’ang’a, Paul M. Mwanje, Mariam T. Bendera, Fatuma S. Bockarie, Moses J. |
author_facet | Njenga, Sammy M. Ng’ang’a, Paul M. Mwanje, Mariam T. Bendera, Fatuma S. Bockarie, Moses J. |
author_sort | Njenga, Sammy M. |
collection | PubMed |
description | BACKGROUND: Soil-transmitted helminths and schistosomiasis are mostly prevalent in developing countries due to poor sanitation and lack of adequate clean water. School-age children tend to be the target of chemotherapy-based control programmes because they carry the heaviest worm and egg burdens. The present study examines adverse events (AEs) experienced following co-administration of albendazole and praziquantel to school-age children in a rural area in Kwale County, Kenya. METHODS: Children were treated with single doses of albendazole and praziquantel tablets and then interviewed using a questionnaire for post treatment AEs. RESULTS: Overall, 752 children, 47.6% boys, participated in the study. Their median (interquartile range) age was 12.0 (10.0–14.0) years. A total of 190 (25.3%) children reportedly experienced at least one AE. In total, 239 cases of AEs were reported with the most frequent being abdominal pains (46.3%), dizziness (33.2%) and nausea (21.1%). Majority of the reported AEs (80.8%) resolved themselves while 12.1% and 6.3% were countered by, respectively, self-medication and visiting a nearby health facility. More girls (60.5%) than boys (39.5%) reported AEs (P = 0.027). CONCLUSIONS: The AEs were mild and transient, and were no worse than those expected following monotherapy. The current study adds to the evidence base that dual administration of albendazole and praziquantel in school-based mass drug administration is safe with only mild adverse events noted. |
format | Online Article Text |
id | pubmed-3919734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39197342014-02-11 A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya Njenga, Sammy M. Ng’ang’a, Paul M. Mwanje, Mariam T. Bendera, Fatuma S. Bockarie, Moses J. PLoS One Research Article BACKGROUND: Soil-transmitted helminths and schistosomiasis are mostly prevalent in developing countries due to poor sanitation and lack of adequate clean water. School-age children tend to be the target of chemotherapy-based control programmes because they carry the heaviest worm and egg burdens. The present study examines adverse events (AEs) experienced following co-administration of albendazole and praziquantel to school-age children in a rural area in Kwale County, Kenya. METHODS: Children were treated with single doses of albendazole and praziquantel tablets and then interviewed using a questionnaire for post treatment AEs. RESULTS: Overall, 752 children, 47.6% boys, participated in the study. Their median (interquartile range) age was 12.0 (10.0–14.0) years. A total of 190 (25.3%) children reportedly experienced at least one AE. In total, 239 cases of AEs were reported with the most frequent being abdominal pains (46.3%), dizziness (33.2%) and nausea (21.1%). Majority of the reported AEs (80.8%) resolved themselves while 12.1% and 6.3% were countered by, respectively, self-medication and visiting a nearby health facility. More girls (60.5%) than boys (39.5%) reported AEs (P = 0.027). CONCLUSIONS: The AEs were mild and transient, and were no worse than those expected following monotherapy. The current study adds to the evidence base that dual administration of albendazole and praziquantel in school-based mass drug administration is safe with only mild adverse events noted. Public Library of Science 2014-02-10 /pmc/articles/PMC3919734/ /pubmed/24520365 http://dx.doi.org/10.1371/journal.pone.0088315 Text en © 2014 Njenga et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Njenga, Sammy M. Ng’ang’a, Paul M. Mwanje, Mariam T. Bendera, Fatuma S. Bockarie, Moses J. A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya |
title | A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya |
title_full | A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya |
title_fullStr | A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya |
title_full_unstemmed | A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya |
title_short | A School-Based Cross-Sectional Survey of Adverse Events following Co-Administration of Albendazole and Praziquantel for Preventive Chemotherapy against Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis in Kwale County, Kenya |
title_sort | school-based cross-sectional survey of adverse events following co-administration of albendazole and praziquantel for preventive chemotherapy against urogenital schistosomiasis and soil-transmitted helminthiasis in kwale county, kenya |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919734/ https://www.ncbi.nlm.nih.gov/pubmed/24520365 http://dx.doi.org/10.1371/journal.pone.0088315 |
work_keys_str_mv | AT njengasammym aschoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT ngangapaulm aschoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT mwanjemariamt aschoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT benderafatumas aschoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT bockariemosesj aschoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT njengasammym schoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT ngangapaulm schoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT mwanjemariamt schoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT benderafatumas schoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya AT bockariemosesj schoolbasedcrosssectionalsurveyofadverseeventsfollowingcoadministrationofalbendazoleandpraziquantelforpreventivechemotherapyagainsturogenitalschistosomiasisandsoiltransmittedhelminthiasisinkwalecountykenya |