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Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia
The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, whole putaminal binding of dopamine D(2)-like recept...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919754/ https://www.ncbi.nlm.nih.gov/pubmed/24520350 http://dx.doi.org/10.1371/journal.pone.0088121 |
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author | Black, Kevin J. Snyder, Abraham Z. Mink, Jonathan W. Tolia, Veeral N. Revilla, Fredy J. Moerlein, Stephen M. Perlmutter, Joel S. |
author_facet | Black, Kevin J. Snyder, Abraham Z. Mink, Jonathan W. Tolia, Veeral N. Revilla, Fredy J. Moerlein, Stephen M. Perlmutter, Joel S. |
author_sort | Black, Kevin J. |
collection | PubMed |
description | The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, whole putaminal binding of dopamine D(2)-like receptor radioligands is quantitatively decreased, but it has not been known whether selected parts of the putamen are differentially affected depending upon the body part affected by dystonia. The radioligand [(18)F]spiperone binds predominantly to D(2)-like receptors in striatum. We hypothesized that the spatial location of [(18)F]spiperone binding within the putamen would differ in patients with dystonia limited to the hand versus the face, and we tested that hypothesis using positron emission tomography and magnetic resonance imaging. To address statistical and methodological concerns, we chose a straightforward but robust image analysis method. An automated algorithm located the peak location of [(18)F]spiperone binding within the striatum, relative to a brain atlas, in each of 14 patients with cranial dystonia and 8 patients with hand dystonia. The mean (left and right) |x|, y, and z coordinates of peak striatal binding for each patient were compared between groups by t test. The location of peak [(18)F]spiperone binding within the putamen differed significantly between groups (cranial dystonia z<hand dystonia z, p = 0.016). We conclude that in isolated focal dystonia, dopamine D(2)-like receptors are distributed differently in the putamen depending on the body part manifesting dystonia. |
format | Online Article Text |
id | pubmed-3919754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39197542014-02-11 Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia Black, Kevin J. Snyder, Abraham Z. Mink, Jonathan W. Tolia, Veeral N. Revilla, Fredy J. Moerlein, Stephen M. Perlmutter, Joel S. PLoS One Research Article The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen. In isolated focal dystonia, whole putaminal binding of dopamine D(2)-like receptor radioligands is quantitatively decreased, but it has not been known whether selected parts of the putamen are differentially affected depending upon the body part affected by dystonia. The radioligand [(18)F]spiperone binds predominantly to D(2)-like receptors in striatum. We hypothesized that the spatial location of [(18)F]spiperone binding within the putamen would differ in patients with dystonia limited to the hand versus the face, and we tested that hypothesis using positron emission tomography and magnetic resonance imaging. To address statistical and methodological concerns, we chose a straightforward but robust image analysis method. An automated algorithm located the peak location of [(18)F]spiperone binding within the striatum, relative to a brain atlas, in each of 14 patients with cranial dystonia and 8 patients with hand dystonia. The mean (left and right) |x|, y, and z coordinates of peak striatal binding for each patient were compared between groups by t test. The location of peak [(18)F]spiperone binding within the putamen differed significantly between groups (cranial dystonia z<hand dystonia z, p = 0.016). We conclude that in isolated focal dystonia, dopamine D(2)-like receptors are distributed differently in the putamen depending on the body part manifesting dystonia. Public Library of Science 2014-02-10 /pmc/articles/PMC3919754/ /pubmed/24520350 http://dx.doi.org/10.1371/journal.pone.0088121 Text en © 2014 Black et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Black, Kevin J. Snyder, Abraham Z. Mink, Jonathan W. Tolia, Veeral N. Revilla, Fredy J. Moerlein, Stephen M. Perlmutter, Joel S. Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia |
title | Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia |
title_full | Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia |
title_fullStr | Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia |
title_full_unstemmed | Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia |
title_short | Spatial Reorganization of Putaminal Dopamine D(2)-Like Receptors in Cranial and Hand Dystonia |
title_sort | spatial reorganization of putaminal dopamine d(2)-like receptors in cranial and hand dystonia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919754/ https://www.ncbi.nlm.nih.gov/pubmed/24520350 http://dx.doi.org/10.1371/journal.pone.0088121 |
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